Wolpers C
Dtsch Med Wochenschr. 1986 Aug 1;111(31-32):1186-91. doi: 10.1055/s-2008-1068605.
Between 1950 and 1980, a total of 145 patients with pain-free gallstones in the gallbladder and open cystic duct were followed for a mean observation period of 13.5 years. Pigment stones made up 25.5% of the total, cholesterol the rest. Growth of stones was noted in 70% of cases, new stones in 14%, and calcification in 25%. Colics occurred in 29%, severe ulcerative cholecystitis in 4% and passage of stones with pancreatitis in 5.5%. Constant cystic duct occlusion occurred in 18%, causing mild gallbladder inflammation in 40% of them. Cholecystectomy should be limited to large, old stones, to prevent gallstone ileus. Recently formed cholesterol stones should be removed as soon as possible by litholysis. Otherwise expectant waiting with regular follow-up is indicated.
1950年至1980年间,对145例胆囊无痛性结石且胆囊管开放的患者进行了随访,平均观察期为13.5年。色素结石占总数的25.5%,其余为胆固醇结石。70%的病例发现结石增大,14%出现新结石,25%发生钙化。29%的患者出现胆绞痛,4%发生严重溃疡性胆囊炎,5.5%的患者结石伴胰腺炎排出。18%发生胆囊管持续阻塞,其中40%导致轻度胆囊炎。胆囊切除术应限于大的、陈旧的结石,以预防胆石性肠梗阻。新形成的胆固醇结石应尽快通过溶石治疗取出。否则,建议进行定期随访的观察等待。