Grosse H
Arch Geschwulstforsch. 1977;47(8):710-8.
Among 22,868 autopsied adults were 7,411 cases with cholelithiasis or cholecystectomy. In the cancerous gallbladders pigment-stones, pure crystalline cholesterol stones and lobulates stones were seldom found but multiple faceted stones and solitary combined stones are more frequent. If the partial volume of gallstones increased, there were more cases with cholecystitis or later carcinoma. Nevertheless in males with all forms of gallstones, carcinoma of the lung, the stomach, the colon and rectum and the prostatic gland were more frequent then carcinoma of the gallbladder. Only in female with multiple faceted stones and solitary combined stones, carcinoma of the gallbladder was the most frequent cancer. The "Störfeld" of the gallbladder with stones is more important for the localisation of a later carcinoma in female then for men. If the gallbladder with stones should be resected in good time, the patient is protected of the risk of cancer of gallbladder, but the percentage of all cancers among inoperated cases with gallstones is not higher than among cases with previons cholecystectomy. Instead of carcinoma of the gallbladder other cancers develop after cholecystectomy.
在22868例接受尸检的成年人中，有7411例患有胆石症或接受过胆囊切除术。在癌性胆囊中，色素结石、纯结晶胆固醇结石和分叶状结石很少见，但多面结石和孤立性混合结石更为常见。如果胆结石的部分体积增大，胆囊炎或晚期癌的病例就更多。然而，在患有各种形式胆结石的男性中，肺癌、胃癌、结肠癌和直肠癌以及前列腺癌比胆囊癌更为常见。只有在患有多面结石和孤立性混合结石的女性中，胆囊癌是最常见的癌症。有结石的胆囊的“Störfeld”对女性晚期癌的定位比男性更为重要。如果及时切除有结石的胆囊，患者可避免胆囊癌的风险，但在未手术的胆结石病例中，所有癌症的百分比并不高于先前接受过胆囊切除术的病例。胆囊切除术后会发生其他癌症而非胆囊癌。
