Department of Blood Transfusion, Central Hospital of Weihai, Weihai, Shandong Province, China.
Clin Appl Thromb Hemost. 2023 Jan-Dec;29:10760296231180170. doi: 10.1177/10760296231180170.
To investigate the clinical application of thromboelastography (TEG) in severe fever with thrombocytopenia syndrome (SFTS).
One hundred and fifty-seven patients with SFTS were included in the study. The participants were distributed into 3 groups; A, B, and C. And 103 patients in group A met the clinical criteria as they exhibited slight liver and kidney dysfunction. Group B consisted of 54 patients with SFTS who were critically ill while group C was a healthy control group with 58 participants.
Patients with SFTS exhibited lower coagulation than the healthy participants. Group B patients exhibited significantly lower coagulation compared to group A. There was no significant difference in platelet count and fibrinogen content between patients in group A and group B, but platelet aggregation function and fibrinogen activity were significantly lower in group B patients.
Our results suggest that it is risky to solely rely on platelet count and the fibrinogen in SFTS. Monitoring of TEG and other coagulation indexes should be emphasized.
探讨血栓弹力图（TEG）在发热伴血小板减少综合征（SFTS）中的临床应用。
本研究纳入了 157 例 SFTS 患者。将参与者分为 3 组；A、B 和 C 组。A 组 103 例患者符合临床标准，表现为轻度肝肾功能障碍。B 组 54 例 SFTS 患者病情危重，C 组为 58 例健康对照组。
SFTS 患者的凝血功能低于健康参与者。B 组患者的凝血功能明显低于 A 组。A 组和 B 组患者的血小板计数和纤维蛋白原含量无显著差异，但 B 组患者的血小板聚集功能和纤维蛋白原活性明显降低。
我们的研究结果表明，仅依靠血小板计数和纤维蛋白原来判断 SFTS 是有风险的。应重视 TEG 及其他凝血指标的监测。
