Mayo Clinic School of Medicine, Jacksonville, FL, USA.
Department of Radiology, Mayo Clinic College of Medicine, Jacksonville, FL, USA.
Neuroradiol J. 2024 Jun;37(3):342-350. doi: 10.1177/19714009241240315. Epub 2024 Mar 15.
Recent studies have suggested an association between dysfunction of the choroid plexus and the glymphatic system. However, information is inconclusive. Following a population-based study design, we aimed to assess the association between choroid plexus calcifications (CPCs)-as a surrogate of choroid plexus dysfunction-and severity and progression of putative markers of glymphatic dysfunction, including white matter hyperintensities (WMH) of presumed vascular origin and abnormally enlarged basal ganglia perivascular spaces (BG-PVS).
This study recruited community-dwellers aged ≥40 years living in neighboring Ecuadorian villages. Participants who had baseline head CTs and brain MRIs were included in cross-sectional analyses and those who additional had follow-up MRIs (after a mean of 6.4 ± 1.5 years) were included in longitudinal analyses. Logistic and Poisson regression models, adjusted for demographics and cardiovascular risk factors, were fitted to assess associations between CPCs and WMH and enlarged BG-PVS severity and progression.
A total of 590 individuals were included in the cross-sectional component of the study, and 215 in the longitudinal component. At baseline, 25% of participants had moderate-to-severe WMH and 27% had abnormally enlarged BG-PVS. At follow-up, 36% and 20% of participants had WMH and enlarged BG-PVS progression, respectively. Logistic regression models showed no significant differences between CPCs volumes stratified in quartiles and severity of WMH and enlarged BG-PVS. Poisson regression models showed no association between the exposure and WMH and enlarged BG-PVS progression. Baseline age remained significant in these models.
Choroid plexus calcifications are not associated with putative markers of glymphatic system dysfunction.
最近的研究表明脉络丛功能障碍与糖质系统之间存在关联。然而，目前的信息尚无定论。我们采用基于人群的研究设计，旨在评估脉络丛钙化（CPCs）——作为脉络丛功能障碍的替代标志物——与假定的糖质系统功能障碍标志物的严重程度和进展之间的关系，包括推测为血管起源的脑白质高信号（WMH）和异常扩大的基底节血管周围间隙（BG-PVS）。
本研究招募了居住在厄瓜多尔邻近村庄的年龄≥40 岁的社区居民。对基线头部 CT 和脑部 MRI 检查的参与者进行了横断面分析，对另外还进行了随访 MRI（平均随访时间为 6.4±1.5 年）的参与者进行了纵向分析。采用逻辑和泊松回归模型，调整了人口统计学和心血管危险因素，以评估 CPCs 与 WMH 和扩大的 BG-PVS 严重程度和进展之间的关系。
共有 590 名参与者纳入了研究的横断面部分，215 名参与者纳入了纵向部分。基线时，25%的参与者有中重度 WMH，27%的参与者有异常扩大的 BG-PVS。随访时，36%和 20%的参与者分别有 WMH 和扩大的 BG-PVS 进展。逻辑回归模型显示，根据 CPCs 体积的四分位数分层，与 WMH 和扩大的 BG-PVS 严重程度之间没有显著差异。泊松回归模型显示，暴露与 WMH 和扩大的 BG-PVS 进展之间没有关联。在这些模型中，基线年龄仍然是显著的。
脉络丛钙化与糖质系统功能障碍的假定标志物无关。
