Forouhari Ali, Heidari-Beni Motahar, Veisi Shaahin, Poursafa Parnian, Kelishadi Roya
Isfahan Eye Research Center, Department of Ophthalmology, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Nutrition, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
Arch Public Health. 2023 Jun 15;81(1):106. doi: 10.1186/s13690-023-01122-2.
The association between epigenetic modification of the genes involved in the vitamin D metabolic pathway and vitamin D metabolites' status has been elucidated incompletely. This study aims to review the studies on the mentioned association and create a brighter view of this topic.
A systematic literature search was conducted in Medline database (PubMed), Scopus, and Web of Science up to the end of November 2020. Original articles which reported the effect of epigenetic alteration-methylation level or its changes-of genes involved in vitamin D regulation on the vitamin D metabolites serum level or its changes were included. The National Institutes of Health (NIH) checklist was used to assess the quality of included articles.
Among 2566 records, nine reports were included in the systematic review according to the inclusion and exclusion criteria. Studies discussed the contribution of methylation status of members of the cytochrome P450 family (CYP2R1, CYP27B1, CYP24A1), and Vitamin D Receptor (VDR) genes to vitamin D level variance. CYP2R1 methylation status could regulate the contributing factors affecting the vitamin D serum level and predict response to vitamin D supplementation. Studies revealed that impaired methylation of CYP24A1 occurs in response to an increase in serum level of 25-hydroxyvitamin D (25(OH)D). It is reported that the association between methylation levels of CYP2R1, CYP24A1, and VDR genes and 25(OH)D level is not affected by the methyl-donors bioavailability.
The epigenetic modification of the vitamin D-related genes could explain the vitamin D levels variation among populations. Large-scale clinical trials in various ethnicities are suggested to find the effect of epigenetics on vitamin D response variation.
The systematic review protocol was registered on PROSPERO (registration number: CRD42022306327).
参与维生素D代谢途径的基因的表观遗传修饰与维生素D代谢物状态之间的关联尚未完全阐明。本研究旨在回顾关于上述关联的研究，并对该主题形成更清晰的认识。
截至2020年11月底，在Medline数据库（PubMed）、Scopus和Web of Science中进行了系统的文献检索。纳入报告维生素D调节相关基因的表观遗传改变（甲基化水平或其变化）对维生素D代谢物血清水平或其变化影响的原创文章。使用美国国立卫生研究院（NIH）清单评估纳入文章的质量。
在2566条记录中，根据纳入和排除标准，有9篇报告被纳入系统评价。研究讨论了细胞色素P450家族成员（CYP2R1、CYP27B1、CYP24A1）和维生素D受体（VDR）基因的甲基化状态对维生素D水平差异的影响。CYP2R1甲基化状态可调节影响维生素D血清水平的因素，并预测对维生素D补充的反应。研究表明，CYP24A1甲基化受损是对血清25-羟基维生素D（25(OH)D）水平升高的反应。据报道，CYP2R1、CYP24A1和VDR基因的甲基化水平与25(OH)D水平之间的关联不受甲基供体生物利用度的影响。
维生素D相关基因的表观遗传修饰可以解释不同人群中维生素D水平的差异。建议开展针对不同种族的大规模临床试验，以探究表观遗传学对维生素D反应差异的影响。
该系统评价方案已在PROSPERO上注册（注册号：CRD42022306327）。
Zotero 插件