Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur (UNS), Bahía Blanca, Argentina.
Hospital Municipal de Agudos "Dr. Leónidas Lucero", Bahía Blanca, Argentina.
Biochem Med (Zagreb). 2023 Jun 15;33(2):020705. doi: 10.11613/BM.2023.020705.
Although current guidelines recommend not drinking coffee prior to phlebotomy, our hypothesis is that drinking coffee does not affect the clinical interpretation of biochemical and haematological test results.
Twenty-seven volunteers were studied in basal state (T0) and 1h after (T1) drinking coffee. Routine haematological (Sysmex-XN1000 analyser) and biochemistry parameters (Vitros 4600 analyser) were studied. Results were compared using the Wilcoxon test (P < 0.05). A clinical change was considered when mean percent difference (MD%) was higher than the reference change value (RCV).
Coffee intake produced statistically, but not clinically, significant: i) increases in haemoglobin (P = 0.009), mean cell haemoglobin concentration (P = 0.044), neutrophils (P = 0.001), albumin (P = 0.001), total protein (P = 0.000), cholesterol (P = 0.025), high density lipoprotein cholesterol (P = 0.007), uric acid (P = 0.011), calcium (P = 0.001), potassium (P = 0.010), aspartate aminotransferase (P = 0.001), amylase (P = 0.026), and lactate dehydrogenase (P = 0.001), and ii) decreases in mean cell volume (P = 0.002), red cell distribution width (P = 0.001), eosinophils (P = 0.002), and lymphocytes (P = 0.001), creatinine (P = 0.001), total bilirubin (P = 0.012), phosphorus (P = 0.001), magnesium (P = 0.007), and chloride (P = 0.001).
Drinking a cup of coffee 1 hour prior to phlebotomy produces no clinically significant changes in routine biochemical and haematological test results.
尽管目前的指南建议在采血前不要喝咖啡，但我们的假设是喝咖啡不会影响生化和血液测试结果的临床解读。
27 名志愿者在基础状态（T0）和饮用咖啡后 1 小时（T1）进行研究。常规血液学（Sysmex-XN1000 分析仪）和生化参数（Vitros 4600 分析仪）进行研究。使用 Wilcoxon 检验（P < 0.05）比较结果。当平均百分比差异（MD%）高于参考变化值（RCV）时，认为存在临床变化。
咖啡摄入产生了统计学上但不是临床上显著的变化：i）血红蛋白（P = 0.009）、平均红细胞血红蛋白浓度（P = 0.044）、中性粒细胞（P = 0.001）、白蛋白（P = 0.001）、总蛋白（P = 0.000）、胆固醇（P = 0.025）、高密度脂蛋白胆固醇（P = 0.007）、尿酸（P = 0.011）、钙（P = 0.001）、钾（P = 0.010）、天门冬氨酸氨基转移酶（P = 0.001）、淀粉酶（P = 0.026）和乳酸脱氢酶（P = 0.001）升高，ii）平均红细胞体积（P = 0.002）、红细胞分布宽度（P = 0.001）、嗜酸性粒细胞（P = 0.002）和淋巴细胞（P = 0.001）、肌酐（P = 0.001）、总胆红素（P = 0.012）、磷（P = 0.001）、镁（P = 0.007）和氯（P = 0.001）降低。
采血前 1 小时饮用一杯咖啡不会对常规生化和血液测试结果产生临床显著变化。
