分析前阶段：在一个年轻女性小队列中，禁食期间饮水对常规血液学参数的影响。
Preanalytical phase: Effects of water ingestion during fasting on routine hematological parameters in a small cohort of young women.
机构信息
Cátedra Bioquímica Clínica I, Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur, Bahía Blanca, Provincia de Buenos Aires, Argentina.
Cátedra Bioquímica Clínica I, Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur, Bahía Blanca, Provincia de Buenos Aires, Argentina; Hospital Municipal de Agudos "Dr. Leónidas Lucero", Bahía Blanca, Provincia de Buenos Aires, Argentina.
出版信息
Clin Chim Acta. 2018 Aug;483:126-129. doi: 10.1016/j.cca.2018.04.019. Epub 2018 Apr 17.
BACKGROUND
We analyze the effects of water ingestion before blood extraction on routine hematological parameters.
METHODS
Twenty female volunteers -mean 24 y- were included. Blood was collected after a 12 h fast period (T) and 1 h after the ingestion of 300 ml water (T). These parameters were analyzed: white blood cell (WBC) count; WBC differential count including lymphocytes (LYM), monocytes (MONO), neutrophils, eosinophils (EOS), and basophils; red blood cell (RBC) count; hematocrit (HCT); hemoglobin (HGB); mean cell volume; mean cell hemoglobin; RBC distribution width; and platelet count (PLT). Statistical significance: P < 0.05. Mean difference % (MD%) was calculated for each parameter and was compared with reference change value (RCV). A change was considered clinically significant when MD% exceeded the RCV.
RESULTS
Significant differences were observed in (medians, T vs T, P): WBC ×10/l (6.51 vs 6.12, 0.002); LYM ×10/l (2.90 vs 2.19, 0.000); MONO ×10/l (0.50 vs 0.48, 0.031); EOS ×10/l (0.17 vs 0.16, 0.003); RBC ×10/l (4.46 vs 4.40, 0.024); HCT l/l (0.38 vs 0.37, 0.036); HGB g/l (129 vs 129, 0.009). All MDs% were lower than their respective RCV.
CONCLUSION
Ingestion of 300 ml water 1 h before blood extraction does not alter the hematological parameters studied.
背景
我们分析了在采血前饮水对常规血液学参数的影响。
方法
纳入 20 名女性志愿者，平均年龄 24 岁。在禁食 12 小时后（T 时间点）和饮水 300 毫升后 1 小时（T 时间点）采集血液。分析以下参数：白细胞（WBC）计数；WBC 分类计数，包括淋巴细胞（LYM）、单核细胞（MONO）、中性粒细胞、嗜酸性粒细胞（EOS）和嗜碱性粒细胞；红细胞（RBC）计数；红细胞压积（HCT）；血红蛋白（HGB）；平均红细胞体积；平均红细胞血红蛋白；红细胞分布宽度；血小板计数（PLT）。统计学意义：P＜0.05。计算每个参数的平均差异百分比（MD%），并与参考变化值（RCV）进行比较。当 MD%超过 RCV 时，认为有临床意义的变化。
结果
T 时间点与 T 时间点相比，（中位数，P）：WBC×10/l（6.51 与 6.12，0.002）；LYM×10/l（2.90 与 2.19，0.000）；MONO×10/l（0.50 与 0.48，0.031）；EOS×10/l（0.17 与 0.16，0.003）；RBC×10/l（4.46 与 4.40，0.024）；HCT l/l（0.38 与 0.37，0.036）；HGB g/l（129 与 129，0.009）。所有 MD%均低于相应的 RCV。
结论
在采血前 1 小时饮用 300 毫升水不会改变所研究的血液学参数。
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