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参考值变化对橡胶工人肺功能测定结果解读的影响

Effects of changing reference values on the interpretation of spirometry for rubber workers.

作者信息

López Alex, Benavides-Cordoba Vicente, Palacios Mauricio

机构信息

Maestría en Salud Ocupacional, Universidad del Valle, Cali, Colombia.

Farmacología, Universidad del Valle, Cali, Colombia.

出版信息

Toxicol Rep. 2023 May 27;10:686-689. doi: 10.1016/j.toxrep.2023.05.011. eCollection 2023.

Abstract

INTRODUCTION

The National Health and Nutrition Assessment Survey (NHANES) is being adopted for interpreting spirometry in occupational examinations. Rubber workers have an elevated risk of respiratory health issues due to industrial exposure, and changes in the equations would affect spirometry monitoring programs.

OBJECTIVE

To determine the differences in the use of the Knudson and NHANES III equations in nonsmoking workers in the rubber industry.

METHOD

A cross-sectional study was conducted with 75 nonsmoking workers with occupational exposure to rubber for at least two years. The factory had engineered protection controls and provided respiratory protection to the workers. Spirometry was conducted according to Spirometry Testing in Occupational Health Programs and Standardization of Spirometry: American Thoracic Society/European Respiratory Society.

RESULT

Spirometric prediction differences were present in the restrictive pattern assessment based on forced vital capacity (FVC), in which three individuals (4%) classified as normal according to Knudson presented restrictive disease according to NHANES III; only in the record of one participant was there restrictive disease using both equations. There was an 8% discrepancy for small airway obstruction in which six workers classified as normal using NHANES III were classified as diseased (FEF 25-75 <50%) using the Knudson equation.

CONCLUSION

In the respiratory examination of workers exposed to rubber, the NHANES III equation is better able to detect restrictive diseases than is the Knudson equation; however, the Knudson equation is more sensitive to obstructive patterns.

摘要

引言

全国健康与营养评估调查(NHANES)正被用于职业检查中肺活量测定结果的解读。由于工业接触,橡胶工人呼吸系统健康问题的风险较高,而方程的变化会影响肺活量测定监测项目。

目的

确定橡胶行业非吸烟工人使用努德森方程和NHANES III方程的差异。

方法

对75名职业接触橡胶至少两年的非吸烟工人进行了横断面研究。工厂设有工程防护措施,并为工人提供呼吸防护。肺活量测定按照《职业健康项目中的肺活量测定测试》和《肺活量测定标准化:美国胸科学会/欧洲呼吸学会》进行。

结果

在基于用力肺活量(FVC)的限制性模式评估中存在肺活量测定预测差异,其中根据努德森方程被判定为正常的3名个体(4%),根据NHANES III方程则呈现限制性疾病;只有1名参与者的记录显示使用两种方程均诊断为限制性疾病。在小气道阻塞方面存在8%的差异,其中6名根据NHANES III方程判定为正常的工人,根据努德森方程被判定为患病(FEF 25 - 75<50%)。

结论

在对接触橡胶的工人进行呼吸检查时,NHANES III方程比努德森方程更能检测出限制性疾病;然而,努德森方程对阻塞性模式更敏感。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/309a/10265506/4484e41307fc/ga1.jpg

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