Rabacchi S, Rocca P, Strata P
Exp Brain Res. 1986;63(1):191-6. doi: 10.1007/BF00235663.
In Wistar rats we have studied the effect of inferior olive lesion or activation on the threshold of a flexor reflex elicited by a nociceptive stimulus applied to the hindpaw. When the inferior olive is lesioned by means of 3-acetylpyridine, the threshold value is significantly decreased. A recovery occurs in 3-4 weeks. When the inferior olive is activated by means of harmaline, the threshold value is significantly increased. These experiments suggest the inferior olive activity exerts an inhibitory effect on flexor reflex activity. The recovery of the threshold value depends, probably, on the plastic reorganization of the cerebellar circuits, which occurs after inferior olive lesion.
在Wistar大鼠中，我们研究了下橄榄核损伤或激活对后爪施加伤害性刺激所引发的屈肌反射阈值的影响。当通过3-乙酰吡啶损伤下橄榄核时，阈值显著降低。在3至4周内会出现恢复。当通过槟榔碱激活下橄榄核时，阈值显著升高。这些实验表明，下橄榄核的活动对屈肌反射活动具有抑制作用。阈值的恢复可能取决于下橄榄核损伤后发生的小脑回路的可塑性重组。
