Roy Harekrishna, Maddiboyina Balaji, Nayak Bhabani Shankar, Bohara Raghvendra A
Department of Pharmaceutics, Nirmala College of Pharmacy Mangalagiri Guntur Andhra Pradesh India
Scientific Writing Services, Medical and Scientific Communications CoE, Freyr Global Regulatory Solutions & Services, Phoenix SEZ Hyderabad India.
RSC Adv. 2025 Jun 4;15(23):18715-18731. doi: 10.1039/d5ra00399g. eCollection 2025 May 29.
Androgenetic alopecia (AGA) is currently the most prevalent cause of hair loss on the scalp. The daily administration of finasteride (FINA) by oral route may lead to the development of numerous undesirable systemic side effects. However, commercially available dermal dosage forms are available only with minoxidil; few studies have claimed severe side effects. Our study deals with the development of solid lipid nanoparticles (SLNs) of FINA with a suitable combination of l-α-phosphatidylcholine (LPC) and -trimethyl chitosan (NTC) to overcome limitations along with good skin retention and hair growth. FINA-SLNs were developed using the ultrasonication technique and characterized further, along with hair growth observed in the animal model. The formulation NP7 showed the highest zeta potential value of -16.5 mV. The absence of the [double bond, length as m-dash]NH peak in the H-NMR spectra could be due to the protons attached, which have substantial exchangeability and result in a probable disappearance in the NMR spectra. The investigation showed the highest skin retention of 226.76 μg of FINA by NP7, along with a modest amount of FINA permeated (71.23 μg) during the study period of 18 h. The animal model using C57BL/6 mice showed a notable enhancement in hair covering and growth in Group IV, which received treatment without any visible cutaneous reaction on the skin. This outcome underscores the effectiveness and importance of the formulation developed using a suitable combination of LPC and NTC, which could be used to manage AGA effectively.
雄激素性脱发（AGA）是目前头皮脱发最常见的原因。口服非那雄胺（FINA）可能会导致多种不良的全身副作用。然而，市面上现有的皮肤剂型仅含米诺地尔；很少有研究表明其有严重副作用。我们的研究致力于开发含FINA的固体脂质纳米粒（SLN），将l-α-磷脂酰胆碱（LPC）和三甲基壳聚糖（NTC）进行适当组合，以克服局限性，同时实现良好的皮肤滞留和促进头发生长。采用超声技术制备了FINA-SLN，并进一步对其进行表征，同时观察动物模型中的头发生长情况。制剂NP7的最高zeta电位值为-16.5 mV。H-NMR谱中[双键，长度为m破折号]NH峰的缺失可能是由于所连接的质子具有显著的交换性，导致在NMR谱中可能消失。研究表明，NP7在皮肤中的FINA保留量最高，为226.76 μg，在18小时的研究期间，还有适量的FINA渗透（71.23 μg）。使用C57BL/6小鼠的动物模型显示，接受治疗的IV组毛发覆盖和生长显著增强，且皮肤无任何可见的皮肤反应。这一结果强调了使用LPC和NTC适当组合开发的制剂的有效性和重要性，该制剂可有效用于治疗AGA。
