Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Department of Radiology, Martini Hospital, Groningen, The Netherlands.
PLoS One. 2023 Jun 16;18(6):e0287383. doi: 10.1371/journal.pone.0287383. eCollection 2023.
Predicted lung volumes based on the Global Lung Function Initiative (GLI) model are used in pulmonary disease detection and monitoring. It is unknown how well the predicted lung volume corresponds with computed tomography (CT) derived total lung volume (TLV). The aim of this study was to compare the GLI-2021 model predictions of total lung capacity (TLC) with CT-derived TLV. 151 female and 139 male healthy participants (age 45-65 years) were consecutively selected from a Dutch general population cohort, the Imaging in Lifelines (ImaLife) cohort. In ImaLife, all participants underwent low-dose, inspiratory chest CT. TLV was measured by an automated analysis, and compared to predicted TLC based on the GLI-2021 model. Bland-Altman analysis was performed for analysis of systematic bias and range between limits of agreement. To further mimic the GLI-cohort all analyses were repeated in a subset of never-smokers (51% of the cohort). Mean±SD of TLV was 4.7±0.9 L in women and 6.2±1.2 L in men. TLC overestimated TLV, with systematic bias of 1.0 L in women and 1.6 L in men. Range between limits of agreement was 3.2 L for women and 4.2 L for men, indicating high variability. Performing the analysis with never-smokers yielded similar results. In conclusion, in a healthy cohort, predicted TLC substantially overestimates CT-derived TLV, with low precision and accuracy. In a clinical context where an accurate or precise lung volume is required, measurement of lung volume should be considered.
基于全球肺功能倡议 (GLI) 模型预测的肺容积用于肺病的检测和监测。目前尚不清楚预测的肺容积与计算机断层扫描 (CT) 得出的总肺容积 (TLV) 之间的相关性如何。本研究旨在比较 GLI-2021 模型预测的肺总量 (TLC) 与 CT 得出的 TLV。从荷兰一般人群队列（影像学在生命队列 [ImaLife] ）中连续选择了 151 名女性和 139 名男性健康参与者（年龄 45-65 岁）。在 ImaLife 中，所有参与者都接受了低剂量吸气式胸部 CT 检查。TLV 通过自动分析进行测量，并与基于 GLI-2021 模型预测的 TLC 进行比较。采用 Bland-Altman 分析评估系统偏差和界限内的范围。为了进一步模拟 GLI 队列，在从不吸烟者亚组（队列的 51%）中重复了所有分析。女性的 TLV 平均值±标准差为 4.7±0.9 L，男性为 6.2±1.2 L。TLC 高估了 TLV，女性的系统偏差为 1.0 L，男性为 1.6 L。女性的界限内范围为 3.2 L，男性为 4.2 L，表明变异性较大。对从不吸烟者进行分析得出了类似的结果。总之，在健康队列中，预测的 TLC 大大高估了 CT 得出的 TLV，其精确度和准确性较低。在需要准确或精确的肺容积的临床情况下，应考虑测量肺容积。
