Department of Pharmaceutical Chemistry, M. M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana 133207, India.
Department of Pharmaceutical Sciences, School of Applied Sciences and Technology, University of Kashmir, Hazratbal, Srinagar 190006, J & K, India.
J Inorg Biochem. 2023 Sep;246:112290. doi: 10.1016/j.jinorgbio.2023.112290. Epub 2023 Jun 10.
Xanthine and its derivatives are considered an important class of N-heterocyclic purine compounds that have gained significant importance in medicinal chemistry. N-heterocyclic carbene (NHC) and N-coordinated metal complexes of xanthine and its derivatives have revealed a range of new possibilities for their use as therapeutic agents in addition to their established catalytic behavior. The metal complexes of xanthine and its derivatives have been designed and synthesized for the exploration of their potential therapeutic applications. These metal complexes based on the xanthine scaffold exhibited various potential medicinal applications including anticancer, antibacterial, and antileishmanial activity. The metal complexes of xanthine and its derivatives shall pave the way for the rational design and development of new therapeutic agents. In the present comprehensive review, we highlighted the recent advancements in the synthesis and medicinal applications of metal complexes based on N-heterocyclic carbene (NHC) derived from xanthine scaffolds.
黄嘌呤及其衍生物被认为是一类重要的 N-杂环嘌呤化合物，在药物化学中具有重要意义。N-杂环卡宾（NHC）和 N-配位的金属配合物的黄嘌呤及其衍生物的发现，除了它们已确立的催化行为外，为它们作为治疗剂的用途提供了一系列新的可能性。黄嘌呤及其衍生物的金属配合物已经被设计和合成，以探索它们作为治疗剂的潜在应用。这些基于黄嘌呤骨架的金属配合物表现出各种潜在的药用应用，包括抗癌、抗菌和抗利什曼原虫活性。黄嘌呤及其衍生物的金属配合物将为合理设计和开发新的治疗剂铺平道路。在本综述中，我们重点介绍了基于 N-杂环卡宾（NHC）的金属配合物的合成和药用应用的最新进展。
