Nayak Swarnagowri, Gaonkar Santosh L
Department of Chemistry, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India.
ChemMedChem. 2021 May 6;16(9):1360-1390. doi: 10.1002/cmdc.202000836. Epub 2021 Feb 23.
New weapons are constantly needed in the fight against cancer. The discovery of cisplatin as an anticancer drug prompted the search for new metal complexes. The successful history of cisplatin motivated chemists to develop a plethora of metal-based molecules. Among them, metal-N-heterocyclic carbene (NHC) complexes have gained significant attention because of their suitable qualities for efficient drug design. The enhanced applications of coinage metal-NHC complexes have encouraged a gradually increasing number of studies in the fields of medicinal chemistry that benefit from the fascinating chemical properties of these complexes. This review aims to present recent developments in synthetic strategies and medicinal applications of copper, silver and gold complexes supported by NHC ligands.
对抗癌症的斗争中始终需要新的武器。顺铂作为一种抗癌药物的发现促使人们寻找新的金属配合物。顺铂的成功历史激励化学家开发了大量基于金属的分子。其中，金属-N-杂环卡宾（NHC）配合物因其具备高效药物设计的合适特性而备受关注。货币金属-NHC配合物应用的增加促使药物化学领域的研究逐渐增多，这些研究受益于这些配合物迷人的化学性质。本综述旨在介绍由NHC配体支持的铜、银和金配合物的合成策略和药用应用的最新进展。
