Division of Cell Biology and Immunology, Biomedical Parasitology and Translational-immunology Lab, CSIR-Institute of Microbial Technology (IMTECH), Sec-39A, Chandigarh-160036, India; Academy of Scientific and Innovation Research (AcSIR), Ghaziabad 201002, India.
Institute of Science, Nirma University, SG highway, Ahmedabad-382481, India.
Drug Discov Today. 2023 Aug;28(8):103671. doi: 10.1016/j.drudis.2023.103671. Epub 2023 Jun 16.
Rheumatoid arthritis (RA) is an inflammatory, autoimmune and connective-tissue arthropathy. The methotrexate (MTX) and aceclofenac (ACL) combination drug regimen is known to regulate the immunological pathways. Also, RA-elicited inflammation is decreased by the combination drug treatment. ACL and MTX combination treatment has been shown to regulate the signaling pathway controlled by NF-κB and FOXO1. The present manuscript reviews the importance of the combination drug regimen to treat and/or manage RA. The combination drug regimen could affect the Th1/Th17 axis to switch the balance toward the immunoregulatory (Th1) phenotype for establishing immune homeostasis. In conclusion, we propose the study of the immunological signaling pathways in experimental humanized RA mice.
类风湿性关节炎（RA）是一种炎症性、自身免疫性和结缔组织关节病。甲氨蝶呤（MTX）和双氯芬酸（ACL）联合药物方案被认为可以调节免疫途径。此外，联合药物治疗还可以减轻 RA 引起的炎症。ACL 和 MTX 联合治疗已被证明可以调节 NF-κB 和 FOXO1 控制的信号通路。本文综述了联合药物方案治疗和/或管理 RA 的重要性。联合药物方案可能会影响 Th1/Th17 轴，使其向免疫调节（Th1）表型倾斜，从而建立免疫平衡。总之，我们建议在实验性人源化 RA 小鼠中研究免疫信号通路。
Fundam Clin Pharmacol. 2014-12
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