Department of Clinical Medicine, Qingdao Medical College, Qingdao University, Qingdao, 266071, Shandong, People's Republic of China.
Department of Radiology, Qilu Hospital of Shandong University (Qingdao), Qingdao, 266035, Shandong, People's Republic of China.
BMC Musculoskelet Disord. 2023 Jun 17;24(1):497. doi: 10.1186/s12891-023-06569-6.
Isthmic spondylolisthesis (IS) is a common clinical disease with a high incidence rate. However, most current researches explain the clear pathogenesis from a single perspective. The aim of our study was to explore the relationships between multiple parameters in patients and find the potential risk factors of this disease.
Our study retrospectively included 115 patients who were diagnosed with isthmic spondylolisthesis and the same number of individuals without spondylolisthesis. The following parameters were measured or collected: age, pelvic incidence (PI), facet joint angle (FJA) and pedicle-facet angle (P-F angle). The radiographic files were imported into Mimics Medical 20.0 and all collected data were analyzed using SPSS, version 26.0, statistical software.
The age was higher in IS group than in control group. PI was also higher in the IS group (50.99 ± 7.67) than in the control group (43.77 ± 9.30) significantly (P = 0.009). There was significant difference in cranial and average FJA tropism in L3-L4 level (P = 0.002, P = 0.006, respectively) and in L4-L5 level (P < 0.001). P-F angle of L4-L5 level showed significantly larger in IS group than in control group (P = 0.007).The logistic regression analysis showed a larger age, a greater L3-L4 cranial FJA tropism, and a greater L4-L5 cranial FJA tropism were potential predictors of IS, with an OR of 1.07, 1.28, and 1.39 respectively. The thresholds of the predictors were 60 years, 5.67°, and 8.97° according to the ROC curve. The linear regression equation was established: degree of slippage (%) = 0.220age - 0.327 L3-4 cranial FJA tropism - 0.346* L4-5 average FJA tropism (F = 3.460, P = 0.011, r = 0.659).
Our study revealed that isthmic spondylolisthesis may be related to multiple factors rather than a single factor. Age, PI, PJA and P-F angle are potentially associated with spondylolisthesis.
峡部裂性脊柱滑脱（IS）是一种常见的临床疾病，发病率较高。然而，目前大多数研究都从单一角度解释其明确的发病机制。本研究旨在探讨患者多种参数之间的关系，寻找该疾病的潜在危险因素。
本研究回顾性纳入 115 例峡部裂性脊柱滑脱患者和相同数量无脊柱滑脱的个体。测量或收集以下参数：年龄、骨盆入射角（PI）、小关节面角（FJA）和椎弓根-小关节面角（P-F 角）。将放射学文件导入 Mimics Medical 20.0，使用 SPSS 26.0 统计软件对所有收集的数据进行分析。
IS 组的年龄高于对照组。IS 组的 PI（50.99±7.67）也显著高于对照组（43.77±9.30）（P=0.009）。在 L3-L4 水平（P=0.002，P=0.006）和 L4-L5 水平（P<0.001），颅侧和平均 FJA 倾向有显著差异。L4-L5 水平的 P-F 角在 IS 组显著大于对照组（P=0.007）。逻辑回归分析显示，年龄较大、L3-L4 颅侧 FJA 倾向较大和 L4-L5 颅侧 FJA 倾向较大是 IS 的潜在预测因素，OR 分别为 1.07、1.28 和 1.39。根据 ROC 曲线，预测因子的阈值分别为 60 岁、5.67°和 8.97°。建立线性回归方程：滑脱程度（%）=0.220年龄-0.327L3-4 颅侧 FJA 倾向-0.346*L4-5 平均 FJA 倾向（F=3.460，P=0.011，r=0.659）。
本研究表明，峡部裂性脊柱滑脱可能与多种因素有关，而不是单一因素。年龄、PI、PJA 和 P-F 角可能与脊柱滑脱有关。
