服用三日疗程的阿莫西林克拉维酸钾来治疗软下疳。
Three day oral course of Augmentin to treat chancroid.
作者信息
Ndinya-Achola J O, Nsanze H, Karasira P, Fransen L, D'Costa L J, Piot P, Ronald A R
出版信息
Genitourin Med. 1986 Jun;62(3):202-4. doi: 10.1136/sti.62.3.202.
Abstract
Amoxycillin and clavulanic acid (Augmentin; Beecham Research Laboratories) was used to treat patients with bacteriologically proved chancroid in three different dose regimens. A single dose of Augmentin (amoxycillin 3 g, clavulanic acid 350 mg) was found to be ineffective. A similar dose repeated after 24 hours was equally ineffective, but a dose (amoxycillin 500 mg, clavulanic acid 250 mg) given every 8 hours for three days was found to be effective. The drug was well tolerated and no side effects were noted in any of the patients treated.
摘要
阿莫西林和克拉维酸（安灭菌；比彻姆研究实验室）被用于以三种不同剂量方案治疗经细菌学证实患有软下疳的患者。发现单剂量的安灭菌（阿莫西林3克，克拉维酸350毫克）无效。24小时后重复给予类似剂量同样无效，但每8小时给予一次（阿莫西林500毫克，克拉维酸250毫克），持续三天的剂量被发现是有效的。该药物耐受性良好，接受治疗的所有患者均未出现副作用。
相似文献
1
Three day oral course of Augmentin to treat chancroid.服用三日疗程的阿莫西林克拉维酸钾来治疗软下疳。
Genitourin Med. 1986 Jun;62(3):202-4. doi: 10.1136/sti.62.3.202.
2
Two dose Augmentin treatment of acute gonorrhoea in men.男性急性淋病的两剂量阿莫西林克拉维酸钾治疗
Br J Vener Dis. 1984 Jun;60(3):161-3. doi: 10.1136/sti.60.3.161.
3
A comparative study of Miraxid (pivmecillinam plus pivampicillin) and Augmentin (amoxycillin plus clavulanic acid) in the treatment of lower respiratory tract infections in general practice.美普清（匹美西林加匹氨西林）与安灭菌（阿莫西林加克拉维酸）治疗全科医疗中下呼吸道感染的对比研究。
J Int Med Res. 1986;14(5):254-60. doi: 10.1177/030006058601400505.
4
Single dose treatment of gonococcal urethritis with augmentin in Ibadan.在伊巴丹使用奥格门汀单剂量治疗淋菌性尿道炎。
Afr J Med Med Sci. 1985 Sep-Dec;14(3-4):169-73.
5
Augmentin in acute exacerbations of chronic bronchitis.阿莫西林克拉维酸钾用于慢性支气管炎急性加重期。
J Int Med Res. 1984;12(6):321-6. doi: 10.1177/030006058401200601.
6
Comparative study of amoxycillin and amoxycillin/clavulanic acid in lower respiratory infections.
J Assoc Physicians India. 1991 Mar;39(3):251-3.
7
Treatment of uncomplicated gonococcal urethritis in males with two doses of Augmentin, six hours apart.
Singapore Med J. 1985 Apr;26(2):147-9.
8
Amoxicillin-clavulanic acid (Augmentin).阿莫西林-克拉维酸（奥格门汀）。
Med Lett Drugs Ther. 1984 Nov 9;26(674):99-100.
9
Single dose oral amoxycillin 3 g with either 125 mg or 250 mg clavulanic acid to treat uncomplicated anogenital gonorrhoea.单次口服3克阿莫西林加125毫克或250毫克克拉维酸，用于治疗无并发症的肛门生殖器淋病。
Genitourin Med. 1985 Jun;61(3):168-71. doi: 10.1136/sti.61.3.168.
10
Sequential intravenous-oral amoxycillin/clavulanate (Augmentin) therapy in paediatric hospital practice.
J Antimicrob Chemother. 1987 Mar;19(3):385-91. doi: 10.1093/jac/19.3.385.
引用本文的文献
1
Antimicrobial susceptibilities of southern African isolates of Haemophilus ducreyi.非洲南部杜克雷嗜血杆菌分离株的抗菌药敏性
Antimicrob Agents Chemother. 1988 Sep;32(9):1458-60. doi: 10.1128/AAC.32.9.1458.
2
Beta-lactamase inhibitors from laboratory to clinic.从实验室到临床的β-内酰胺酶抑制剂
Clin Microbiol Rev. 1988 Jan;1(1):109-23. doi: 10.1128/CMR.1.1.109.
3
Treatment of chancroid.软下疳的治疗
Antimicrob Agents Chemother. 1990 Jul;34(7):1308-11. doi: 10.1128/AAC.34.7.1308.
4
Antimicrobial susceptibility of Haemophilus ducreyi.杜克雷嗜血杆菌的抗菌药敏性。
Antimicrob Agents Chemother. 1990 Jul;34(7):1303-7. doi: 10.1128/AAC.34.7.1303.
5
Amoxicillin/clavulanic acid. An update of its antibacterial activity, pharmacokinetic properties and therapeutic use.阿莫西林/克拉维酸：抗菌活性、药代动力学特性及治疗用途的最新进展
Drugs. 1990 Feb;39(2):264-307. doi: 10.2165/00003495-199039020-00008.
本文引用的文献
1
Epidemiologic, clinical, laboratory, and therapeutic features of an urban outbreak of chancroid in North America.北美城市软下疳暴发的流行病学、临床、实验室及治疗特征
Rev Infect Dis. 1980 Nov-Dec;2(6):867-79. doi: 10.1093/clinids/2.6.867.
2
Genital ulcers in Kenya. Clinical and laboratory study.肯尼亚的生殖器溃疡。临床与实验室研究。
Br J Vener Dis. 1981 Dec;57(6):378-81. doi: 10.1136/sti.57.6.378.
3
Antimicrobial therapy of chancroid: an evaluation of five treatment regimens correlated with in vitro sensitivity.软下疳的抗菌治疗：五种治疗方案与体外敏感性相关性的评估
Sex Transm Dis. 1983 Jan-Mar;10(1):1-6.
4
Single-dose therapy of chancroid with trimethoprim-sulfametrole.用甲氧苄啶-磺胺甲噁唑单剂量治疗软下疳。
N Engl J Med. 1983 Jul 14;309(2):67-71. doi: 10.1056/NEJM198307143090202.
5
Treatment of chancroid by clavulanic acid with amoxycillin in patients with beta-lactamase-positive Haemophilus ducreyi infection.
Lancet. 1982 Sep 4;2(8297):509-11. doi: 10.1016/s0140-6736(82)90597-9.
Zotero 插件