Harvey M H, Morris B A, McMillan M, Marks V
Hum Toxicol. 1986 Jul;5(4):249-53. doi: 10.1177/096032718600500406.
Spoiled potatoes and, in particular, steroidal alkaloids have been proposed as an aetiological factor in the pathogenesis of neural tube defect (NTD). The present study involves the measurement of potato (solanum) steroidal alkaloid concentrations in serum by radioimmunoassay. Serum solanidine and total potato alkaloid concentrations were measured in two groups of women: one group pregnant with a fetus, subsequently shown to be affected by a NTD, the other with a healthy fetus. Serum alkaloid concentrations were, contrary to expectations, lower in the NTD group. They lend no weight therefore to the theory that potato alkaloids are responsible for NTD, but are consistent with the opinion that some water-soluble vitamins lessen the risk.
变质土豆，尤其是其中的甾体生物碱，已被提出是神经管缺陷（NTD）发病机制中的一个病因因素。本研究涉及通过放射免疫分析法测定血清中土豆（茄属）甾体生物碱浓度。对两组女性的血清茄碱和总土豆生物碱浓度进行了测量：一组怀有胎儿，随后显示胎儿受神经管缺陷影响，另一组怀有健康胎儿。与预期相反，神经管缺陷组的血清生物碱浓度较低。因此，它们无法支持土豆生物碱导致神经管缺陷的理论，但与某些水溶性维生素可降低风险的观点一致。
