Harvey M H, McMillan M, Morgan M R, Chan H W
Hum Toxicol. 1985 Mar;4(2):187-94. doi: 10.1177/096032718500400209.
Solanidine, a steroidal alkaloid, and its glycosides have been reported to have caused poisoning in man and animals. These alkaloids are normally present in small amounts in potatoes. Measurement of solanidine in body fluid would be expected to establish the real incidence of acute toxicity and help to resolve the question of any chronic toxicity including teratogenicity. We report the detection of solanidine in the serum of 57 normal healthy volunteer subjects in whom it measured 4.0-56.3 nmol/l (1.6-22.5 ng/ml) before the midday meal. There was a significant correlation between serum solanidine concentration and normal dietary intake of potato by the individual concerned. When two subjects abstained from potato and its products serum solanidine fell markedly and became minimal after the second week onwards.
茄碱，一种甾体生物碱，及其糖苷已被报道可导致人和动物中毒。这些生物碱通常在马铃薯中含量较少。测定体液中的茄碱有望确定急性毒性的实际发生率，并有助于解决包括致畸性在内的任何慢性毒性问题。我们报告了在57名正常健康志愿者的血清中检测到茄碱，在午餐前其含量为4.0 - 56.3纳摩尔/升（1.6 - 22.5纳克/毫升）。血清茄碱浓度与相关个体的正常马铃薯饮食摄入量之间存在显著相关性。当两名受试者 abstained from马铃薯及其制品时，血清茄碱明显下降，从第二周开始降至最低水平。 （注：abstained from这个短语原英文有误，推测是“abstained from eating”，这里先按原英文翻译，整体意思受此影响可能不太准确，完整准确意思应是“当两名受试者停止食用马铃薯及其制品时” ）
