Department of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029. China.
Department of Anesthesiology, Taizhou People's Hospital Affiliated to Nanjing Medical University, No. 399 Hailing South Road, Taizhou City 225300, Jiangsu Province, China.
Brain Res Bull. 2023 Aug;200:110691. doi: 10.1016/j.brainresbull.2023.110691. Epub 2023 Jun 17.
Patients with chronic pain often suffer with depressive symptoms, and these two conditions can be aggravated by each other over time, leading to an increase in symptom intensity and duration. The comorbidity of pain and depression poses a significant challenge to human health and quality of life, as it is often difficult to diagnose early and treat effectively. Therefore, exploring the molecular mechanisms underlying the comorbidity of chronic pain and depression is crucial to identifying new therapeutic targets for treatment. However, understanding the pathogenesis of comorbidity requires examining interactions among multiple factors, which calls for an integrative perspective. While several studies have explored the role of the GABAergic system in pain and depression, fewer have examined its interactions with other systems involved in their comorbidity. Here, we review the evidence that the role of GABAergic system in the comorbidity of chronic pain and depression, as well as the interactions between the GABAergic system and other secondary systems involved in pain and depression comorbidity, providing a comprehensive understanding of their intricate interplay.
患有慢性疼痛的患者常伴有抑郁症状，随着时间的推移，这两种情况可能会相互加重，导致症状强度和持续时间增加。疼痛和抑郁共病对人类健康和生活质量构成了重大挑战，因为早期诊断和有效治疗往往很困难。因此，探索慢性疼痛和抑郁共病的分子机制对于确定新的治疗靶点至关重要。然而，要了解共病的发病机制，需要检查多个因素之间的相互作用，这需要综合的观点。虽然有几项研究探讨了 GABA 能系统在疼痛和抑郁中的作用，但很少有研究检查其与其他涉及共病的系统之间的相互作用。在这里，我们回顾了 GABA 能系统在慢性疼痛和抑郁共病中的作用，以及 GABA 能系统与参与疼痛和抑郁共病的其他二级系统之间的相互作用的证据，全面了解它们错综复杂的相互作用。
