National Medical Research Center of Cardiology named after Academician E. I. Chazov, Ministry of Health of the Russian Federation, Moscow, 121552, Russia.
Biochemistry (Mosc). 2023 May;88(5):698-703. doi: 10.1134/S0006297923050127.
It has been established that acylhydroperoxy derivatives of phospholipids from oxidized rat liver mitochondria are captured predominantly by LDL particles but not by HDL during co-incubation with blood plasma lipoproteins, which refutes the previously suggested hypothesis about the involvement of HDL in the reverse transport of oxidized phospholipids and confirms the possibility of different mechanisms of lipohydroperoxide accumulation in LDL during oxidative stress.
已经证实，在与血漿脂蛋白共孵育時，氧化的鼠肝線粒體磷脂的羥基羥基衍生物主要被 LDL 顆粒而非 HDL 捕獲，這推翻了先前關於 HDL 參與氧化磷脂逆向轉運的假說，並確認了在氧化應激期間 LDL 中脂羥基積累可能存在不同機制。
