National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia.
Dokl Biochem Biophys. 2022 Dec;507(1):294-297. doi: 10.1134/S1607672922060072. Epub 2023 Feb 14.
Oxidatively modified plasma lipoproteins play an important role in the molecular mechanisms of vascular wall damage in atherosclerosis and diabetes mellitus. It was found that the oxidizability of low-density lipoproteins (LDLs) is more than one order of magnitude higher than that of high-density lipoproteins (HDLs). It was shown that acylhydroperoxy derivatives of phospholipids of oxidized biomembranes are predominantly captured by LDL particles, but not by HDLs, which refutes the hypothesis about the involvement of HDLs in the reverse transport of lipohydroperoxides (LOOH). The results suggest the possibility of different mechanisms of LOOH accumulation in LDLs: due to the increased oxidizability of LDLs and due to the effective transmembrane transport of LOOH by LDL particles.
氧化修饰的血浆脂蛋白在动脉粥样硬化和糖尿病的血管壁损伤的分子机制中起着重要作用。研究发现，低密度脂蛋白（LDL）的氧化易感性比高密度脂蛋白（HDL）高出一个数量级以上。研究表明，氧化生物膜的磷脂酰基氢过氧化物衍生物主要被 LDL 颗粒捕获，而不是被 HDL 捕获，这反驳了关于 HDL 参与脂氢过氧化物（LOOH）反向转运的假说。研究结果表明，LDL 中 LOOH 积累的机制可能不同：由于 LDL 的氧化易感性增加，以及 LDL 颗粒有效跨膜转运 LOOH。
