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主动物理治疗联合气道正压通气对心脏手术后肺不张的影响:一项随机对照研究。

Effect of Active Physiotherapy With Positive Airway Pressure on Pulmonary Atelectasis After Cardiac Surgery: A Randomized Controlled Study.

机构信息

Service de kinésithérapie, hôpital Laënnec, CHU Nantes, Nantes, France.

Nantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France; Nantes Université, CHU Nantes, Service d'Anesthésie Réanimation, hôpital Laënnec, INSERM CIC 0004 Immunologie et Infectiologie, Nantes, France.

出版信息

J Cardiothorac Vasc Anesth. 2023 Sep;37(9):1668-1676. doi: 10.1053/j.jvca.2023.05.043. Epub 2023 May 30.

Abstract

OBJECTIVES

The authors investigated the effect of active work with positive airway pressure (PAP) in addition to chest physiotherapy (CP) on pulmonary atelectasis (PA) in patients undergoing cardiac surgery with cardiopulmonary bypass.

DESIGN

A randomized controlled study.

SETTING

At a single-center tertiary hospital.

PARTICIPANTS

Eighty adult patients undergoing cardiac surgery (coronary artery bypass grafting, valve surgery, or both), and presenting with PA after tracheal extubation on postoperative days 1 or 2, were randomized from November 2014 to September 2016.

INTERVENTION

Three days of CP, twice daily, associated with active work with PAP effect (intervention group) versus CP alone (control group). Pulmonary atelectasis was assessed by using the radiologic atelectasis score (RAS) measured from daily chest x-rays. All radiographs were reviewed blindly.

MEASUREMENTS AND MAIN RESULTS

Among included patients, 79 (99%) completed the trial. The primary outcome was mean RAS on day 2 after inclusion. It was significantly lower in the intervention group (mean difference and 95% CI: -1.1 [-1.6 to -0.6], p < 0.001). The secondary outcomes were the sniff nasal inspiratory pressure measured before and after CP and clinical variables. Sniff nasal inspiratory pressure was significantly higher in the intervention group on day 2 (7.7 [3.0-12.5] cmHO, p = 0.002). The respiratory rate was lower in the intervention group (-3.2 [95% CI -4.8 to -1.6] breaths/min, p < 0.001) on day 2. No differences were found between the 2 groups for percutaneous oxygen saturation/oxygen requirement ratio, heart rate, pain, and dyspnea scores.

CONCLUSIONS

Active work with the PAP effect, combined with CP, significantly decreased the RAS of patients undergoing cardiac surgery after 2 days of CP, with no differences observed in clinically relevant parameters.

摘要

目的

作者研究了在心肺转流术后气管拔管后第 1 或 2 天出现肺不张(PA)的患者中,除胸部物理治疗(CP)之外积极使用正压通气(PAP)对 PA 的影响。

设计

一项随机对照研究。

设置

在一家单中心三级医院。

参与者

2014 年 11 月至 2016 年 9 月,80 名成年患者接受了心脏手术(冠状动脉旁路移植术、瓣膜手术或两者兼有),在术后第 1 或 2 天拔管后出现 PA,被随机分为两组:CP 联合积极使用 PAP 效果(干预组)和 CP 单独治疗(对照组)。通过每日胸部 X 射线测量放射学肺不张评分(RAS)来评估肺不张。所有 X 光片均进行了盲法评估。

测量和主要结果

在纳入的患者中,79 名(99%)完成了试验。主要结局是纳入后第 2 天的平均 RAS。干预组明显更低(平均差异和 95%CI:-1.1[-1.6 至-0.6],p<0.001)。次要结局为 CP 前后测量的嗅探鼻吸气压力和临床变量。CP 后第 2 天,干预组的嗅探鼻吸气压力明显升高(7.7[3.0-12.5]cmH2O,p=0.002)。干预组第 2 天的呼吸频率较低(-3.2[95%CI-4.8 至-1.6]次/分钟,p<0.001)。两组间经皮血氧饱和度/氧需求比、心率、疼痛和呼吸困难评分无差异。

结论

CP 联合 PAP 效果的积极使用,显著降低了 CP 后 2 天心脏手术后患者的 RAS,而在临床相关参数方面没有差异。

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