School & Hospital of Stomatology, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, PR China.
Department of Oral Implantology, School & Hospital of Stomatology, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, PR China.
Br J Oral Maxillofac Surg. 2023 Jul;61(6):403-410. doi: 10.1016/j.bjoms.2023.05.005. Epub 2023 May 16.
Evidence is limited on whether titanium-zirconium alloy, narrow-diameter implants (Ti-Zr NDIs) have promising clinical outcomes when used to support single crowns. The purpose of this systematic review and meta-analysis was to evaluate clinical evidence, including survival rates, success rates, and marginal bone loss (MBL) on Ti-Zr NDIs that support single crowns. An extensive search was performed in the databases of PubMed/MEDLINE, Scopus, Embase, and the Cochrane Library for studies published in English up to April 2022. Only peer-reviewed clinical studies with at least 10 patients and a follow-up time of at least 12 months were included. Risk of bias in each study was assessed and data extraction was carried out independently by two reviewers. The outcome variables were survival rates, success rates, and MBL. The search returned 779 results. Eight studies were identified for qualitative analysis and seven for quantitative synthesis. Overall, a total of 256 Ti-Zr NDIs were included. Cumulative implant survival rates and success rates were 97.5% (95% confidence interval (CI): 94.5% to 98.9%) and 97.2% (95% CI: 94.2% to 98.7%), respectively, over a maximum follow-up period of 36 months, with no difference between Ti-Zr NDIs and commercial pure titanium (cpTi) implants. Cumulative mean (SD) MBL was 0.44 (0.04) mm (95% CI: 0.36 to 0.52) after one year. Meta-analysis of MBL indicated a mean difference of 0.02 mm (95% CI: -0.23 to 0.10), with no differences between Ti-Zr NDIs and cpTi implants. Short-term results of Ti-Zr NDIs for single-crown restorations are quite promising, although the number of published studies and follow-up periods are insufficient to determine the real benefit for single crowns. Long-term, follow-up clinical studies are needed to verify the excellent clinical performance of Ti-Zr NDIs.
关于钛锆合金（Ti-Zr）窄径种植体（Ti-Zr NDIs）用于单冠修复的临床效果，目前相关证据有限。本系统评价和荟萃分析旨在评估临床证据，包括 Ti-Zr NDIs 支持单冠的生存率、成功率和边缘骨吸收（MBL）。我们在 PubMed/MEDLINE、Scopus、Embase 和 Cochrane Library 数据库中全面检索了截至 2022 年 4 月发表的英文文献。仅纳入了至少有 10 名患者、随访时间至少 12 个月的同行评议的临床研究。对每项研究的偏倚风险进行评估，并由两名评审员独立进行数据提取。主要观察指标为生存率、成功率和 MBL。检索共得到 779 项结果，其中 8 项研究进行定性分析，7 项研究进行定量综合分析。共纳入 256 枚 Ti-Zr NDIs。在最长 36 个月的随访期内，Ti-Zr NDIs 的累积种植体生存率和成功率分别为 97.5%（95%置信区间（CI）：94.5%98.9%）和 97.2%（95% CI：94.2%98.7%），与商业纯钛（cpTi）种植体无差异。1 年后，MBL 的累积平均（SD）值为 0.44（0.04）mm（95% CI：0.360.52）。MBL 的荟萃分析表明，平均差值为 0.02mm（95% CI：-0.230.10），Ti-Zr NDIs 与 cpTi 种植体之间无差异。尽管目前发表的研究数量和随访时间还不足以确定 Ti-Zr NDIs 用于单冠修复的真实获益，但 Ti-Zr NDIs 用于单冠修复的短期效果相当有前景。需要进行长期的随访临床研究，以验证 Ti-Zr NDIs 的优异临床性能。
