Charité-Universitätsmedizin Berlin, Department of Oral and Maxillofacial Surgery, Berlin, Germany.
Private Practice DDr. Holzinger, Kindberg, Austria.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2023 Sep;136(3):308-314. doi: 10.1016/j.oooo.2023.02.011. Epub 2023 Feb 24.
The study aimed to assess the usefulness of a bovine bone substitute material in treating cystic lesions in the jaw with a maximum diameter of <4 cm.
In this prospective, randomized, single-blind intervention study of 116 patients, 61 underwent cystectomy with a subsequent filling of the defect using a bovine xenograft, and 55 underwent cystectomy alone. Volumetric measurement of the cysts was performed preoperatively and 6 and 12 months postoperatively using the available digital volume tomography data sets. Follow-up appointments were made 14 days and 1, 3, 6, and 12 months postoperatively.
Almost complete regeneration was seen in both treatment groups within 12 months, with no significant difference in absolute volume loss between the 2 groups (P = .521). Examination 14 days after surgery revealed a tendency for more wound healing disorders with the use of a bone substitute (P = .077). It was no longer possible to detect any further differences in later examinations.
Using bovine bone substitute material has no radiologically measurable advantage over cystectomy alone without defect filling regarding bone regeneration. In addition, there was a tendency for more wound-healing disorders to occur in the bone substitute group.
本研究旨在评估牛骨替代材料在治疗直径<4cm 的颌骨囊性病变中的应用价值。
在这项前瞻性、随机、单盲干预研究中，纳入了 116 名患者，其中 61 例行囊切除术，并用牛异种移植物填充缺损；55 例行单纯囊切除术。使用现有数字容积断层扫描数据集，分别于术前、术后 6 个月和 12 个月对囊肿进行体积测量。术后 14 天和 1、3、6、12 个月进行随访。
两组患者在 12 个月内几乎均实现完全再生，两组间的绝对体积丢失无显著差异（P=0.521）。术后 14 天检查发现，使用骨替代物的患者有更多的伤口愈合障碍的趋势（P=0.077）。在后续的检查中，这种差异不再明显。
与单纯行囊切除术而不填充缺损相比，使用牛骨替代材料在骨再生方面并无放射学可测量的优势。此外，骨替代物组的伤口愈合障碍发生趋势更高。
