Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, China.
Clin Implant Dent Relat Res. 2022 Aug;24(4):468-474. doi: 10.1111/cid.13099. Epub 2022 May 16.
This study was aimed to evaluate bone healing after jaw cyst enucleation with or without bone substitutes by cone beam computed tomography, and to analyze potential influence factors for bone formation as well.
Sixty seven jaw cyst patients were randomly assigned to two groups. Thirty three patients in control group accepted cystectomy without any filling material. The rest 34 bone cavities which filled with xenograft (DBBM, Bio-Oss®) and covered by absorbable membrane (Bio-Gide®) were included in the guided bone regeneration (GBR) group. All patients were examined with cone bean computerized tomography before operation, 3 and 6 months after surgery. Linear regression analysis was applied to evaluate the influence factors of bone healing.
There was no significant difference in bone formation rate at 3 months after enucleation, with shrinkage rate (SR) of cystic lesion in control group and GBR group of 26.43 ± 14.98% and 20.78 ± 10.80%, respectively (p > 0.05). Larger shrinkage area in GBR group was detected on postoperative radiographs after 6 months with SR of 60.11 ± 19.23%, when compared to those in patients without filling (6 months SR: 48.63 ± 19.39%, p = 0.018, <0.05). Linear regression analysis showed that cyst size was negatively correlated with bone formation.
GBR with bovine xenograft and absorbable membrane showed considerable bone regeneration property in the healing of jaw cystic defects after enucleation of radicular cysts. Cyst size showed a suppressive influence on bone formation.
本研究旨在通过锥形束 CT 评估颌骨囊肿切除术后是否使用骨替代物的骨愈合情况，并分析骨形成的潜在影响因素。
67 例颌骨囊肿患者被随机分为两组。对照组 33 例患者接受囊肿切除术，不使用任何填充材料。其余 34 例骨腔填充异种移植物（DBBM、Bio-Oss®）并用可吸收膜（Bio-Gide®）覆盖的患者被纳入引导骨再生（GBR）组。所有患者在术前、术后 3 个月和 6 个月均进行锥形束计算机断层扫描检查。线性回归分析用于评估骨愈合的影响因素。
术后 3 个月，囊腔病变的骨形成率无显著差异，对照组和 GBR 组的退缩率（SR）分别为 26.43±14.98%和 20.78±10.80%（p>0.05）。术后 6 个月，GBR 组的影像学显示骨腔病变退缩面积较大，SR 为 60.11±19.23%，而未填充组的 SR 为 6 个月时为 48.63±19.39%（p=0.018，<0.05）。线性回归分析表明，囊肿大小与骨形成呈负相关。
在根端囊肿切除术后颌骨囊性缺损的愈合中，牛异种移植物和可吸收膜的 GBR 具有相当的骨再生特性。囊肿大小对骨形成有抑制作用。
