[不同阶段创伤性脊髓损伤的干细胞移植研究进展]
[Advances in stem cell transplantation for traumatic spinal cord injury at different stages].
作者信息
Jin Yuanzhi, Rong Xin, Liu Hao
机构信息
Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P. R. China.
出版信息
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2023 Jun 15;37(6):721-726. doi: 10.7507/1002-1892.202302028.
OBJECTIVE
To summarize the research progress of stem cell transplantation in treating spinal cord injury (SCI) at different stages based on the pathophysiological mechanism of SCI.
METHODS
The relevant research literature at home and abroad was extensively reviewed to explore the impact of transplantation timing on the effectiveness of stem cell transplantation in treating SCI.
RESULTS
Researchers performed different types of stem cell transplantation for subjects at different stages of SCI through different transplantation approaches. Clinical trials have proved the safety and feasibility of stem cell transplantation at acute, subacute, and chronic stages, which can alleviate inflammation at the injured site and restore the function of the damaged nerve cells. But the reliable clinical trials comparing the effectiveness of stem cell transplantation at different stages of SCI are still lacking.
CONCLUSION
Stem cell transplantation has a good prospect in treating SCI. In the future, the multi-center, large sample randomized controlled clinical trials are needed, with a focus on the long-term effectiveness of stem cell transplantation.
目的
基于脊髓损伤（SCI）的病理生理机制，总结干细胞移植治疗不同阶段脊髓损伤的研究进展。
方法
广泛查阅国内外相关研究文献，探讨移植时机对干细胞移植治疗脊髓损伤有效性的影响。
结果
研究人员通过不同移植途径，对处于脊髓损伤不同阶段的受试者进行了不同类型的干细胞移植。临床试验已证明干细胞移植在急性、亚急性和慢性阶段的安全性和可行性，其可减轻损伤部位的炎症并恢复受损神经细胞的功能。但仍缺乏比较脊髓损伤不同阶段干细胞移植有效性的可靠临床试验。
结论
干细胞移植治疗脊髓损伤具有良好前景。未来需要开展多中心、大样本随机对照临床试验，重点关注干细胞移植的长期有效性。
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