Graduate School of Human Life Design, Toyo University, 1-7-11 Akabanedai, Kita-Ku 115-8650, Tokyo, Japan.
Japan Society for the Promotion of Science Research Fellowships DC, Tokyo, Japan.
Sci Rep. 2023 Jun 18;13(1):9863. doi: 10.1038/s41598-023-36914-7.
Osgood-Schlatter disease (OSD), a condition that affects adolescents, causes inflammation, pain, and prominence at the tibial tuberosity. The causes of OSD are not well understood, but eccentric contractions in the quadriceps have been suggested as a possible factor. To investigate this, a study was conducted in which 24 rats were divided into two groups: the downhill treadmill running (DR) group and the control (CO) group. The DR group underwent a preliminary running program for 1 week, followed by a main running program for 3 weeks. The results showed that the deep region of the tibial tuberosity in the DR group was larger than that in the CO group, and inflammatory cytokines involved in gene expression were upregulated in the DR group. The anterior articular cartilage and deep region in the DR group were also immunoreactive to substance P. Additionally, high-activity chondrocytes of small size were observed in the non-calcified matrix. Thus, the DR group exhibited symptoms similar to OSD, including inflammation, pain, and prominence. These findings suggest that eccentric contractions in the quadriceps may play a role in the development of OSD. Further research is needed to better understand the pathophysiology of this condition and develop effective treatment options.
Osgood-Schlatter 病（OSD）是一种影响青少年的疾病，会导致胫骨结节处出现炎症、疼痛和突出。OSD 的病因尚不清楚，但股四头肌的离心收缩被认为是一个可能的因素。为了研究这一点，进行了一项研究，将 24 只大鼠分为两组：下坡跑步机跑步（DR）组和对照组（CO）。DR 组进行了为期 1 周的初步跑步计划，然后进行了为期 3 周的主要跑步计划。结果表明，DR 组胫骨结节的深部区域大于 CO 组，并且 DR 组中涉及基因表达的炎症细胞因子上调。DR 组的前关节软骨和深部区域也对 P 物质呈免疫反应。此外，在未钙化基质中观察到小尺寸的高活性软骨细胞。因此，DR 组表现出类似于 OSD 的症状，包括炎症、疼痛和突出。这些发现表明股四头肌的离心收缩可能在 OSD 的发展中起作用。需要进一步研究以更好地了解这种疾病的病理生理学，并开发有效的治疗选择。
