Second College of Clinical Medical, Wenzhou Medical University, Wenzhou, China.
Department of Breast Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Expert Rev Mol Med. 2023 Jun 19;25:e21. doi: 10.1017/erm.2023.16.
Breast cancer is a high-risk disease with a high mortality rate among women. Chemotherapy plays an important role in the treatment of breast cancer. However, chemotherapy eventually results in tumours that are resistant to drugs. In recent years, many studies have revealed that the activation of Wnt/-catenin signalling is crucial for the emergence and growth of breast tumours as well as the development of drug resistance. Additionally, drugs that target this pathway can reverse drug resistance in breast cancer therapy. Traditional Chinese medicine has the properties of multi-target and tenderness. Therefore, integrating traditional Chinese medicine and modern medicine into chemotherapy provides a new strategy for reversing the drug resistance of breast tumours. This paper mainly reviews the possible mechanism of Wnt/-catenin in promoting the process of breast tumour drug resistance, and the progress of alkaloids extracted from traditional Chinese medicine in the targeting of this pathway in order to reverse the drug resistance of breast cancer.
乳腺癌是一种高危疾病，女性死亡率较高。化疗在乳腺癌的治疗中起着重要作用。然而，化疗最终会导致肿瘤对药物产生耐药性。近年来，许多研究表明，Wnt/-catenin 信号的激活对于乳腺癌肿瘤的发生和生长以及耐药性的发展至关重要。此外，靶向该途径的药物可以逆转乳腺癌治疗中的耐药性。中药具有多靶点和温和的特性。因此，将中药与现代医学相结合应用于化疗为逆转乳腺癌肿瘤耐药性提供了一种新策略。本文主要综述了 Wnt/-catenin 促进乳腺癌肿瘤耐药过程的可能机制，以及从中药中提取的生物碱靶向该途径逆转乳腺癌耐药性的研究进展。
