Gao Xin, Yu Yongbo, Wang Haicun, Liu Guanglin, Sun Xinyu, Wang Zhidong, Jiang Xingming
General Surgery Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.
Oncol Lett. 2023 Jun 8;26(1):321. doi: 10.3892/ol.2023.13907. eCollection 2023 Jul.
Circular RNA (circRNA) is a class of endogenous non-coding RNA, a type of single-stranded covalently closed RNA molecule formed by alternative splicing of exons or introns. Previous studies have demonstrated that circRNA participates in modulating biological processes such as cell proliferation, differentiation and apoptosis, and plays key roles in tumor occurrence and development. CircRNA nuclear receptor interacting protein 1 (circ_NRIP1), a form of circRNA, is abnormally expressed in certain human tumor types. It is present at a higher abundance compared with cognate linear transcripts and can regulate malignant biological behaviors such as tumor proliferation, invasion and migration, revealing a currently unexplored frontier in cancer progression. The present review presents a pattern of circ_NRIP1 expression in various malignant tumor types and highlights its significance in cancer development, in addition to its potential as a disease indicator or future therapeutic agent.
环状RNA（circRNA）是一类内源性非编码RNA，是由外显子或内含子的可变剪接形成的单链共价闭合RNA分子。先前的研究表明，circRNA参与调节细胞增殖、分化和凋亡等生物学过程，并在肿瘤的发生和发展中起关键作用。环状RNA核受体相互作用蛋白1（circ_NRIP1）作为circRNA的一种形式，在某些人类肿瘤类型中异常表达。与同源线性转录本相比，它以更高的丰度存在，并可调节肿瘤增殖、侵袭和迁移等恶性生物学行为，揭示了癌症进展中一个目前尚未探索的前沿领域。本综述展示了circ_NRIP1在各种恶性肿瘤类型中的表达模式，并强调了其在癌症发展中的意义，以及其作为疾病指标或未来治疗剂的潜力。
