Ghafouri-Fard Soudeh, Khoshbakht Tayyebeh, Hussen Bashdar Mahmud, Taheri Mohammad, Samsami Majid
Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Cancer Cell Int. 2022 Apr 29;22(1):172. doi: 10.1186/s12935-022-02602-1.
Ovarian cancer is a female malignancy with high fatality-to-case ratio, which is due to late detection of cancer. Understanding the molecular mechanisms participating in these processes would facilitate design of therapeutic modalities and identification of novel tumor markers. Recent investigations have shown contribution of circular RNAs (circRNAs) in the evolution of ovarian cancer. These transcripts are produced through a back-splicing mechanism. The enclosed configuration of circRNAs protects them from degradation and potentiates them as biomarkers. Several circRNAs such as circMUC16, circRNA_MYLK, circRNA-UBAP2, circWHSC1, hsa_circ_0013958, circFGFR3, hsa_circRNA_102958 and circ_0072995 have been found to be up-regulated in this cancer, acting as oncogenes. On the other hand, circ-ITCH, circPLEKHM3, circ_100395, circ_0078607, circATRNL1, circHIPK3, circRHOBTB3, circEXOC6B, circ9119 and CDR1as are among down-regulated circRNAs in ovarian cancer. Expression levels of circCELSR1, circ_CELSR1, circATL2, circNRIP1, circTNPO3 and hsa_circ_0000714 have been shown to affect resistance of ovarian cancer cells to chemotherapy. Moreover, circ_100395, circFGFR3, circ_0000554, circCELSR1, circ-PTK2, circLNPEP, circ-CSPP1, circ_0000745, circ_100395 and circPLEKHM3 have been shown to regulate epithelial-mesenchymal transition and metastatic ability of ovarian cancer cells. In the current review, we explain the roles of circRNAs in the evolution and progression of ovarian cancer.
卵巢癌是一种病死率很高的女性恶性肿瘤，这是由于癌症发现较晚所致。了解参与这些过程的分子机制将有助于设计治疗方案并鉴定新的肿瘤标志物。最近的研究表明，环状RNA（circRNA）在卵巢癌的发生发展中发挥了作用。这些转录本是通过反向剪接机制产生的。circRNA的封闭结构保护它们不被降解，并使其有潜力成为生物标志物。已发现几种circRNA，如circMUC16、circRNA_MYLK、circRNA-UBAP2、circWHSC1、hsa_circ_0013958、circFGFR3、hsa_circRNA_102958和circ_0072995在这种癌症中上调，起癌基因的作用。另一方面，circ-ITCH、circPLEKHM3、circ_100395、circ_0078607、circATRNL1、circHIPK3、circRHOBTB3、circEXOC6B、circ9119和CDR1as是卵巢癌中下调的circRNA。circCELSR1、circ_CELSR1、circATL2、circNRIP1、circTNPO3和hsa_circ_0000714的表达水平已被证明会影响卵巢癌细胞对化疗的耐药性。此外，circ_100395、circFGFR3、circ_0000554、circCELSR1、circ-PTK2、circLNPEP、circ-CSPP1、circ_0000745、circ_100395和circPLEKHM3已被证明可调节卵巢癌细胞的上皮-间质转化和转移能力。在本综述中，我们解释了circRNA在卵巢癌发生发展中的作用。
