细胞角蛋白7阴性原发性肺腺癌
CK-7 negative primary lung adenocarcinoma.
作者信息
Tchienga Dimitri, Ascio Noelani-Mei, Qureshi Abid, Razia Sultana, Romulo Genato, Asarian Armand, Xiao Philip, Nouthe Brice, Belinga Dominique
机构信息
Department of Surgery, St George's University School of Medicine, True Blue, Grenada, WI, USA.
Department of Surgery, The Brooklyn Hospital Center, Icahn School of Medicine at Mount Sinai, Brooklyn, NY, USA.
出版信息
J Surg Case Rep. 2023 Jun 15;2023(6):rjad316. doi: 10.1093/jscr/rjad316. eCollection 2023 Jun.
Cytokeratin (CK) 7 is normally expressed in the vast majority of lung adenocarcinoma (ADC). However, on rare occasions, as reported in this paper, CK7 negativity can challenge the diagnosis of pulmonary ADC. Hence, the need to use a combination of 'immunomarkers' such as thyroid transcription factor 1, Napsin A, p40, p63 and CK20.
细胞角蛋白（CK）7通常在绝大多数肺腺癌（ADC）中表达。然而，如本文所报道的，在极少数情况下，CK7阴性可能会对肺ADC的诊断构成挑战。因此，需要联合使用诸如甲状腺转录因子1、Napsin A、p40、p63和CK20等“免疫标志物”。
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