Vas A, Gachályi B, Nádas B, Kurcz M, Káldor A
Int J Clin Pharmacol Ther Toxicol. 1986 Jul;24(7):377-8.
The authors studied the effect of a 0.5 mg intravenous bolus injection of digoxin on human red blood cell glucose-6-phosphate activity under in vivo circumstances. Digoxin administration resulted in a small but statistically significant rise in the enzyme activity. This effect of digoxin seems to support the hypothesis that the circulating sodium transport inhibitor substance or natriuretic hormone found in a group of patients with essential hypertension may be an endogenous digitalis because the two substances act similarly in this respect.
作者研究了在体内情况下静脉推注0.5毫克地高辛对人红细胞葡萄糖-6-磷酸活性的影响。给予地高辛后，该酶活性出现了虽小但具有统计学意义的升高。地高辛的这一作用似乎支持了以下假说，即在一组原发性高血压患者中发现的循环钠转运抑制物质或利钠激素可能是一种内源性洋地黄制剂，因为这两种物质在这方面的作用相似。
