Chen Lei, Dai Qinglei, Gao Xin, Hu Na, Sun Xiao, Wang Haibo, Wang Mingming
Department of Otolaryngology Head and Neck Surgery, Shandong Provincial ENT Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Department of Otology Medicine, Shandong Provincial ENT Hospital, Shandong University, Jinan, China.
Front Neurol. 2023 Jun 2;14:1174412. doi: 10.3389/fneur.2023.1174412. eCollection 2023.
This study aimed to investigate the clinical features and prognosis of sudden sensorineural hearing loss in patients with lateral semicircular canal (LSCC) malformation.
This study enrolled patients with LSCC malformation and sudden sensorineural hearing loss (SSNHL) who were admitted to Shandong ENT Hospital between 2020 and 2022. We collected and analyzed data on examinations of audiology, vestibular function, and imaging records of patients and summarized the clinical characteristics and prognosis of these patients.
Fourteen patients were enrolled. Patients with LSCC malformation was noted in 0.42% of all SSNHL cases during the same period. One patients had bilateral SSNHL and the rest had unilateral SSNHL. Of them, eight and six patients had unilateral and bilateral LSCC malformations, respectively. Flat hearing loss was noted in 12 ears (80.0%) and severe or profound hearing loss was noted in 10 ears (66.7%). After treatment, the total efficacy rate of SSNHL with LSCC malformation was 40.0%. Vestibular function was abnormal in all patients, but only five patients (35.7%) had dizziness. There were statistically significant differences in the vestibular functions between patients with LSCC malformation and matched patients without the malformation hospitalized during the same period ( < 0.05).
Patients with SSNHL and LSCC malformation had flat-type and severe hearing loss and worse disease prognosis compared to those with SSNHL without LSCC malformation. Vestibular function is more likely to be abnormal; however, there was no significant difference in vestibular symptoms between patients with and without LSCC malformation. LSCC is a risk factor for the prognosis of SSNHL.
本研究旨在探讨伴有外侧半规管（LSCC）畸形的突发性感音神经性听力损失患者的临床特征及预后。
本研究纳入了2020年至2022年期间在山东耳鼻喉医院住院的伴有LSCC畸形及突发性感音神经性听力损失（SSNHL）的患者。我们收集并分析了患者的听力学检查、前庭功能检查及影像学记录数据，并总结了这些患者的临床特征及预后。
共纳入14例患者。同期所有SSNHL病例中，LSCC畸形患者占0.42%。1例患者为双侧SSNHL，其余为单侧SSNHL。其中，8例和6例患者分别有单侧和双侧LSCC畸形。12耳（80.0%）出现平坦型听力损失，10耳（66.7%）出现重度或极重度听力损失。治疗后，伴有LSCC畸形的SSNHL总有效率为40.0%。所有患者前庭功能均异常，但只有5例患者（35.7%）有头晕症状。伴有LSCC畸形的患者与同期住院的无畸形匹配患者的前庭功能存在统计学显著差异（<0.05）。
与不伴有LSCC畸形的SSNHL患者相比，伴有SSNHL和LSCC畸形的患者有平坦型和重度听力损失，疾病预后更差。前庭功能更易异常；然而，伴有和不伴有LSCC畸形的患者在前庭症状方面无显著差异。LSCC是SSNHL预后的一个危险因素。
