Slator Paddy J, Verdera Jordina Aviles, Tomi-Tricot Raphael, Hajnal Joseph V, Alexander Daniel C, Hutter Jana
Centre for Medical Image Computing and Department of Computer Science, University College London, London, United Kingdom.
Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, UK.
medRxiv. 2023 Jun 10:2023.06.06.23290983. doi: 10.1101/2023.06.06.23290983.
Demonstrating quantitative multi-parametric mapping in the placenta with combined -diffusion MRI at low-field (0.55T).
We present 57 placental MRI scans performed on a commercially available 0.55T scanner. We acquired the images using a combined -diffusion technique scan that simultaneously acquires multiple diffusion preparations and echo times. We processed the data to produce quantitative and diffusivity maps using a combined -ADC model. We compared the derived quantitative parameters across gestation in healthy controls and a cohort of clinical cases.
Quantitative parameter maps closely resemble those from previous experiments at higher field strength, with similar trends in and ADC against gestational age observed.
Combined -diffusion placental MRI is reliably achievable at 0.55T. The advantages of lower field strength - such as cost, ease of deployment, increased accessibility and patient comfort due to the wider bore, and increased for larger dynamic ranges - can support the widespread roll out of placental MRI as an adjunct to ultrasound during pregnancy.
利用低场强（0.55T）的联合扩散磁共振成像（MRI）在胎盘中进行定量多参数成像。
我们展示了在商用0.55T扫描仪上进行的57例胎盘MRI扫描。我们使用联合扩散技术扫描获取图像，该技术可同时采集多个扩散准备和回波时间。我们使用联合表观扩散系数（ADC）模型处理数据以生成定量表观扩散系数图和扩散率图。我们比较了健康对照组和一组临床病例中不同孕周的导出定量参数。
定量参数图与先前在更高场强下的实验结果非常相似，观察到表观扩散系数和ADC随孕周的变化趋势相似。
在0.55T场强下可靠地实现联合扩散胎盘MRI。低场强的优势，如成本、易于部署、由于孔径更大而增加的可及性和患者舒适度，以及更大动态范围的更高表观扩散系数，可支持胎盘MRI作为孕期超声辅助手段的广泛应用。
