探索血浆Hsa_circ_0052184作为结直肠癌预后的新型生物标志物
Exploration into Plasma Hsa_circ_0052184 as a New Biomarker of Colorectal Cancer Prognosis.
作者信息
Zheng Enqi, Xiao Deshuang
机构信息
Hernia Vascular Surgery, The First People's Hospital of Wenling, Wenling, Zhejiang, People's Republic of China.
出版信息
Pharmgenomics Pers Med. 2023 Jun 12;16:589-597. doi: 10.2147/PGPM.S413451. eCollection 2023.
BACKGROUND
Circular RNAs (circRNAs) are strong modulators of tumor pathology. Herein, our goal was to examine the plasma hsa_circ_0052184 content among colorectal cancer (CRC) patients, and assess its association with patient clinicopathological profile and diagnostic values.
METHODS
Overall, we collected 228 presurgical CRC and 146 normal plasma samples from The First People's Hospital of Wenling. Circulating hsa_circ_0052184 levels were assessed via qRT-PCR, and the diagnostic prediction was conducted with the receiver operating characteristic (ROC) curve.
RESULTS
Relative to healthy controls, CRC patients exhibited markedly enhanced circulating hsa_circ_0052184 levels, which were closely correlated with advanced stage of disease and worse outcome. Based on our uni- (UA) and multivariate assessments (MA), elevated hsa_circ_0052184 levels were a stand-alone predictor of poor prognosis. The ROC curve depicted an area under the curve (AUC) for CRC diagnosis to be 0.9072.
CONCLUSION
Circulating hsa_circ_0052184 is a potential bioindicator of CRC outcome.
背景
环状RNA（circRNA）是肿瘤病理学的强效调节因子。在此，我们的目标是检测结直肠癌（CRC）患者血浆中hsa_circ_0052184的含量，并评估其与患者临床病理特征及诊断价值的关联。
方法
我们总共从温岭市第一人民医院收集了228份术前CRC血浆样本和146份正常血浆样本。通过qRT-PCR评估循环中hsa_circ_0052184的水平，并使用受试者工作特征（ROC）曲线进行诊断预测。
结果
相对于健康对照，CRC患者循环中hsa_circ_0052184水平显著升高，这与疾病晚期和较差的预后密切相关。基于我们的单因素（UA）和多因素评估（MA），hsa_circ_0052184水平升高是预后不良的独立预测因子。ROC曲线显示CRC诊断的曲线下面积（AUC）为0.9072。
结论
循环中的hsa_circ_0052184是CRC预后的潜在生物指标。
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