Chen Xiaonan, Zhang Dong, Wang Teng, Ma Weiyuan
Department of Hematology, Affiliated Hospital of Weifang Medical University, Weifang, People's Republic of China.
Department of Dermatology, Affiliated Hospital of Weifang Medical University, Weifang, People's Republic of China.
Clin Cosmet Investig Dermatol. 2023 Jun 13;16:1499-1503. doi: 10.2147/CCID.S413592. eCollection 2023.
is an atypical bacterium, and skin infections caused by it are relatively rare, usually occurring in workers engaged in seafood processing and housewives who clean and prepare fish for consumption. The infection often occurs after the skin is punctured by fish scales, spines, etc. The JAK/STAT signaling pathway is closely related to the human immune response to infections. Therefore, JAK inhibitors may induce and exacerbate various infections in clinical practice. This article reports a case of skin infection in the left upper limb of a female patient with chronic idiopathic myelofibrosis during treatment with ruxolitinib. The patient denied being punctured or scratched by fish scales or spines. Clinical manifestations included multiple infiltrative erythemas and subcutaneous nodules in the thumb and forearm. Histopathological examination showed infiltration of mixed acute and chronic inflammatory cells in the subcutaneous tissue. The diagnosis was ultimately confirmed by NGS sequencing. The patient was cured after taking moxifloxacin and clarithromycin for 10 months. Infection is a common adverse reaction of JAK inhibitors, but no literature has reported on skin infections occurring during JAK inhibitor treatment, which is relatively rare. As the clinical application of JAK inhibitors becomes more widespread, the skin infections they cause may present in various forms and require the attention of clinicians.
是一种非典型细菌，由其引起的皮肤感染相对罕见，通常发生在从事海鲜加工的工人以及清洗和处理食用鱼的家庭主妇身上。感染常发生在皮肤被鱼鳞、鱼刺等刺破之后。JAK/STAT信号通路与人类对感染的免疫反应密切相关。因此，JAK抑制剂在临床实践中可能诱发并加重各种感染。本文报告了1例在用鲁索替尼治疗慢性特发性骨髓纤维化的女性患者左上肢皮肤感染的病例。患者否认被鱼鳞或鱼刺刺破或划伤。临床表现为拇指和前臂出现多个浸润性红斑和皮下结节。组织病理学检查显示皮下组织有混合性急性和慢性炎性细胞浸润。最终通过二代测序确诊。患者服用莫西沙星和克拉霉素10个月后治愈。感染是JAK抑制剂常见的不良反应，但尚无文献报道JAK抑制剂治疗期间发生的皮肤感染，这种情况相对罕见。随着JAK抑制剂在临床上的应用越来越广泛，它们引起的皮肤感染可能会以各种形式出现，需要临床医生予以关注。
