Baminiwatta Anuradha, Correll Christoph U
Department of Psychiatry, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
Department of Psychiatry and Molecular Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, United States.
Front Psychiatry. 2023 Jun 2;14:1194222. doi: 10.3389/fpsyt.2023.1194222. eCollection 2023.
Since being recognized as an important drug-induced clinical entity during the 1960s, tardive dyskinesia (TD) has generated an extensive body of research seeking to understand its clinical characteristics, epidemiology, pathophysiology and management. Modern scientometric approaches allow interactive visualization of large bodies of literature to identify trends and hotspots within knowledge domains. This study thus aimed to provide a comprehensive scientometric review of the TD literature.
Web of Science was searched for articles, reviews, editorials and letters with the term "tardive dyskinesia" in the title, abstract, or keywords through 12/31/2021. A total of 5,228 publications and 182,052 citations were included. Annual research output, prominent research areas, authors, affiliations and countries were summarized. VOSViewer and CiteSpace were used for bibliometric mapping and co-citation analysis. Structural and temporal metrics were used to identify key publications in the network.
TD-related publications peaked in the 1990s, gradually declined after 2004, and showed a further small increase after 2015. The most prolific authors were Kane JM, Lieberman JA, and Jeste DV overall (1968-2021), and Zhang XY, Correll CU and Remington G in the last decade (2012-2021). The most prolific journal was the Journal of Clinical Psychiatry overall, and the Journal of Psychopharmacology in the last decade. Knowledge clusters in the 1960-1970s dealt with clinical and pharmacological characterization of TD. In the 1980s, epidemiology, clinical TD assessment, cognitive dysfunction and animal models predominated. During the 1990s, research diverged into pathophysiological studies, especially oxidative stress, and clinical trials on atypical antipsychotics, with a focus on clozapine and bipolar disorder. In the 1990-2000s, pharmacogenetics emerged. More recent clusters include serotonergic receptors, dopamine-supersensitivity psychosis, primary motor abnormalities of schizophrenia, epidemiology/meta-analyses, and advances in TD treatment, particularly vesicular monoamine transporter-2 inhibitors since 2017.
This scientometric review visualized the evolution of scientific knowledge on TD over more than five decades. These findings will be useful for researchers to find relevant literature when writing scientific articles, choosing appropriate journals, finding collaborators or mentors for research, and to understand the historical developments and emerging trends in TD research.
自20世纪60年代被确认为一种重要的药物诱导临床实体以来，迟发性运动障碍（TD）引发了大量研究，旨在了解其临床特征、流行病学、病理生理学和治疗方法。现代科学计量学方法允许对大量文献进行交互式可视化，以识别知识领域内的趋势和热点。因此，本研究旨在对TD文献进行全面的科学计量学综述。
通过在Web of Science中检索标题、摘要或关键词中包含“迟发性运动障碍”一词的文章、综述、社论和信件，检索时间截至2021年12月31日。共纳入5228篇出版物和182052次引用。总结了年度研究产出、突出的研究领域、作者、所属机构和国家。使用VOSViewer和CiteSpace进行文献计量绘图和共被引分析。使用结构和时间指标来识别网络中的关键出版物。
与TD相关的出版物在20世纪90年代达到峰值，2004年后逐渐下降，2015年后又有小幅增长。总体而言，发表文章最多的作者是Kane JM、Lieberman JA和Jeste DV（1968 - 2021年），在过去十年（2012 - 2021年）是Zhang XY、Correll CU和Remington G。总体而言，发表文章最多的期刊是《临床精神病学杂志》，在过去十年是《精神药理学杂志》。20世纪60 - 70年代的知识集群涉及TD的临床和药理学特征。20世纪80年代，流行病学、临床TD评估、认知功能障碍和动物模型占主导地位。20世纪90年代，研究分为病理生理学研究，尤其是氧化应激，以及非典型抗精神病药物的临床试验，重点是氯氮平和双相情感障碍。在20世纪90年代至21世纪初，药物遗传学出现。最近的集群包括血清素能受体、多巴胺超敏性精神病、精神分裂症的原发性运动异常、流行病学/荟萃分析以及TD治疗的进展，特别是自2017年以来的囊泡单胺转运体2抑制剂。
本科学计量学综述展示了五十多年来TD科学知识的演变。这些发现将有助于研究人员在撰写科学文章、选择合适的期刊、寻找研究合作者或导师时找到相关文献，并了解TD研究的历史发展和新趋势。
