College of Physical Education, Changzhou University, Changzhou 213164, China.
Department of Sport and Exercise Science, College of Education, Zhejiang University, Hangzhou 310058, China.
Int J Environ Res Public Health. 2022 May 18;19(10):6153. doi: 10.3390/ijerph19106153.
Irisin is a hormone-like molecule mainly released by skeletal muscles in response to exercise, which is proposed to induce the 'browning' of white adipose tissue. Since its identification, irisin was reported to be closely associated with many metabolic diseases, including type 2 diabetes mellitus (T2DM), obesity, cardiovascular disease (CVD), and metabolic bone diseases. In recent years, irisin has attracted increasing research interest, and numerous studies have been published in this field. Thus, it is essential to identify the current research status of irisin and measure research hotspots and possible future trends. In this study, by utilizing two visualization software named CiteSpace and VOSviewer, we analyzed 1510 Web of Science publications on irisin published from 2012 to 2021. Our results show that the number of irisin-related articles published annually has increased significantly. China participates in the most studies, followed by the United States and Turkey. Firat University, Harvard University, and Shandong University are three major institutions with larger numbers of publications. The analysis of keywords co-occurrence indicates that insulin resistance, inflammation, and circulating irisin levels in serum are the research hotspots. Apoptosis, BDNF, and osteoporosis will likely become the focus of future research related to irisin. Overall, this study may provide helpful insights for researchers to understand the current research situation and identify the potential frontiers of irisin.
鸢尾素是一种主要由骨骼肌在运动时释放的激素样分子，它被认为可以诱导白色脂肪组织的“褐色化”。自被发现以来，鸢尾素被报道与许多代谢性疾病密切相关，包括 2 型糖尿病（T2DM）、肥胖症、心血管疾病（CVD）和代谢性骨病。近年来，鸢尾素引起了越来越多的研究兴趣，该领域发表了大量的研究论文。因此，有必要确定鸢尾素的当前研究状况，并衡量研究热点和可能的未来趋势。在这项研究中，我们使用 CiteSpace 和 VOSviewer 这两种可视化软件，对 2012 年至 2021 年发表的 1510 篇关于鸢尾素的 Web of Science 出版物进行了分析。结果表明，每年发表的鸢尾素相关文章数量显著增加。中国参与的研究最多，其次是美国和土耳其。费拉特大学、哈佛大学和山东大学是发表论文数量较多的三大机构。关键词共现分析表明，胰岛素抵抗、炎症和血清中循环鸢尾素水平是研究热点。细胞凋亡、脑源性神经营养因子和骨质疏松症可能成为未来与鸢尾素相关研究的重点。总之，本研究可为研究人员了解当前研究状况和确定鸢尾素的潜在前沿领域提供有益的见解。
