环状RNA在调节胶质瘤发生发展中的作用。
Roles of circular RNAs in regulating the development of glioma.
作者信息
Fan Jianing, Wang Yangyang, Liang Xiao, Zhou Fanlin, Li Shijie, Li Xiaoju, Li Yu
机构信息
School of Medicine, Chongqing University, Chongqing, China.
Department of Pathology, Chongqing University Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer Hospital, Chongqing, China.
出版信息
J Cancer Res Clin Oncol. 2023 Mar;149(3):979-993. doi: 10.1007/s00432-022-04136-5. Epub 2022 Jul 1.
BACKGROUND
Glioma is the most common malignant tumor in the central nervous system. In patients with glioma, the prognosis is poor and median survival is only 12-15 months. With the recent development of sequencing technology, important roles of noncoding RNAs are being discovered in cells, especially those of circular RNAs (circRNAs). Because circRNAs are stable, abundant, and highly conserved, they are regarded as novel biomarkers in the early diagnosis and prognosis of diseases.
PURPOSE
In this review, roles and mechanisms of circRNAs in the development of glioma are summarized.
METHODS
This paper collects and reviews relevant PubMed literature.
CONCLUSION
Several classes of circRNAs are highly expressed in glioma and are associated with malignant biological behaviors of gliomas, including proliferation, migration, invasion, apoptosis, angiogenesis, and drug resistance. Further studies are needed to clarify the roles of circRNAs in glioma and to determine whether it is possible to increase therapeutic effects on tumors through circRNA intervention.
背景
胶质瘤是中枢神经系统最常见的恶性肿瘤。胶质瘤患者预后较差，中位生存期仅为12 - 15个月。随着测序技术的最新发展，非编码RNA在细胞中的重要作用正在被发现，尤其是环状RNA（circRNA）。由于circRNA稳定、丰富且高度保守，它们被视为疾病早期诊断和预后的新型生物标志物。
目的
在本综述中，总结circRNA在胶质瘤发生发展中的作用及机制。
方法
本文收集并综述了相关的PubMed文献。
结论
几类circRNA在胶质瘤中高表达，并与胶质瘤的恶性生物学行为相关，包括增殖、迁移、侵袭、凋亡、血管生成和耐药性。需要进一步研究以阐明circRNA在胶质瘤中的作用，并确定是否有可能通过circRNA干预提高对肿瘤的治疗效果。
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