Galeazzi L, Holzman J, Mondoloni M, Rochefort J
Department of Oral and Dental Medicine, Pitié-Salpêtrière Hospital Université Paris Cité, UFR Odontologie Paris France.
Clin Case Rep. 2023 Jun 17;11(6):e7560. doi: 10.1002/ccr3.7560. eCollection 2023 Jun.
A 60-year-old female patient, with no notable medical history, was referred by the internal medicine department for a dry mouth workup. The clinical examination revealed an absence of dryness, and the presence of lingual fasciculations, associated with difficulties in mastication and phonation. These symptoms appeared spontaneously 9 months before the consultation, after leaving confinement. Given the presence of lingual fasciculations, the diagnostic hypothesis of a neurological pathology, in particular amyotrophic lateral sclerosis (ALS), was suspected. After performing an electromyogram (EMG), the diagnosis of ALS was retained. Riluzole treatment was then started, and physical therapy sessions were scheduled. Riluzole allows an average gain of 4 to 6 months of life expectancy. Speech therapy and physical therapy allow to maintain the functions as long as possible and to improve the end-of-life conditions. The interest of early detection of ALS allows delaying the progression of the disease.
一名60岁女性患者，无显著病史，由内科转诊进行口干检查。临床检查发现无口干症状，但存在舌肌束颤，伴有咀嚼和发声困难。这些症状在咨询前9个月分娩后自发出现。鉴于存在舌肌束颤，怀疑有神经病理学诊断，尤其是肌萎缩侧索硬化症（ALS）。进行肌电图（EMG）检查后，确诊为ALS。随后开始利鲁唑治疗，并安排了物理治疗课程。利鲁唑可使预期寿命平均延长4至6个月。言语治疗和物理治疗可尽可能长时间维持功能，并改善临终状况。早期发现ALS的意义在于延缓疾病进展。
