Department of Neurology, Ankara University School of Medicine, Ankara, Turkey.
Department of Neurology, University Hospital Schleswig-Holstein, Christian-Albrechts-University, Kiel, Germany.
J Parkinsons Dis. 2023;13(5):819-827. doi: 10.3233/JPD-230037.
Camptocormia (CC) is the forward-bending of the spine of more than 30 degrees that can be found in Parkinson's disease (PD) as a disabling complication. Detection of changes in paraspinal lumbar musculature in CC is of value for choosing treatment strategies.
To investigate whether these changes can be detected using muscle ultrasonography (mUSG).
Age and sex-matched groups comprised 17 PD patients with CC (seven acute, PD-aCC; 10 chronic PD-cCC), 19 PD patients with no CC, and 18 healthy controls (HC). Lumbar paravertebral muscles (LPM) on both sides were assessed using mUSG by two different raters blinded to the group assignment. Groups were compared with regard to the linear measurements of the muscle thickness as well as semi-quantitative and quantitative (grayscale) analyses of muscle echogenicity using a univariate general linear model.
All assessments showed substantial interrater reliability. The PD-cCC group had significantly thinner LPM compared to groups with no CC (PD and HC). Groups of PD-aCC and PD-cCC differed from the groups of no CC in quantitative and semi-quantitative analyses of LPM echogenicity, respectively.
Assessment of LPM in PD patients with CC can be reliably performed using mUSG. Also, mUSG may be used as a screening tool to detect CC-related changes in thickness and echogenicity of the LPM in patients with PD.
脊柱前屈超过 30 度的 Camptocormia（CC）可在帕金森病（PD）中作为一种致残并发症出现。检测 CC 中脊柱旁腰肌的变化对于选择治疗策略具有重要价值。
探讨肌肉超声（mUSG）是否可以检测到这些变化。
年龄和性别匹配的组包括 17 例 CC 的 PD 患者（急性 CC，PD-aCC7 例；慢性 PD-cCC10 例）、19 例无 CC 的 PD 患者和 18 例健康对照者（HC）。由两位对分组情况不知情的不同评估者使用 mUSG 评估双侧椎旁肌（LPM）。使用单变量一般线性模型比较各组肌肉厚度的线性测量值以及肌肉回声的半定量和定量（灰度）分析。
所有评估均具有较高的组内相关性。PD-cCC 组的 LPM 明显比无 CC（PD 和 HC）的组薄。PD-aCC 组和 PD-cCC 组在 LPM 的定量和半定量回声分析方面分别与无 CC 的组存在差异。
使用 mUSG 可以可靠地评估 CC 的 PD 患者的 LPM。此外，mUSG 可能作为一种筛查工具，用于检测 PD 患者 LPM 的厚度和回声变化。
