Department of Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Artif Organs. 2023 Aug;47(8):1262-1266. doi: 10.1111/aor.14546. Epub 2023 Apr 21.
Partial heart transplantation is a new type of transplant that delivers growing heart valve replacements for babies. Partial heart transplantation differs from orthotopic heart transplantation because only the part of the heart containing the heart valve is transplanted. It also differs from homograft valve replacement because viability of the graft is preserved by tissue matching, minimizing donor ischemia times, and recipient immunosuppression. This preserves partial heart transplant viability and allows the grafts to fulfill biological functions such as growth and self-repair. These advantages over conventional heart valve prostheses are balanced by similar disadvantages as other organ transplants, most importantly limitations in donor graft availability. Prodigious progress in xenotransplantation promises to solve this problem by providing an unlimited source of donor grafts. In order to study partial heart xenotransplantation, a suitable large animal model is important. Here we describe our research protocol for partial heart xenotransplantation in nonhuman primates.
部分心脏移植是一种新型的移植，可为婴儿提供不断生长的心脏瓣膜替代物。部分心脏移植与原位心脏移植不同，因为只有包含心脏瓣膜的心脏部分被移植。它也与同种异体瓣膜置换不同，因为通过组织匹配、最大限度地减少供体缺血时间和受者免疫抑制来保留移植物的活力。这保留了部分心脏移植的活力，并允许移植物发挥生长和自我修复等生物学功能。与传统心脏瓣膜假体相比，这些优势被其他器官移植的类似缺点所平衡，最重要的是供体移植物的可用性有限。异种移植的巨大进展有望通过提供无限的供体移植物来源来解决这个问题。为了研究部分心脏异种移植，一个合适的大型动物模型很重要。在这里，我们描述了我们在非人灵长类动物中进行部分心脏异种移植的研究方案。
