Department of Anthropology, University at Albany, Albany, NY, USA.
Center for the Elimination of Minority Health Disparities, University at Albany, Albany, NY, USA.
J Toxicol Environ Health A. 2023 Sep 2;86(17):597-613. doi: 10.1080/15287394.2023.2226685. Epub 2023 Jun 19.
Persistent organic pollutants (POPs) including polychlorinated biphenyls (PCBs), hexachlorobenzene (HCB), and dichlorodiphenyltrichloroethane (-DDT) were reported to influence immunological activity. As endocrine-disrupting chemicals (EDC), these pollutants may disrupt normal thyroid function and act as catalysts for development of autoimmune thyroid disease by directly and indirectly affecting levels of thyroid peroxidase antibodies (TPOAbs). Native American communities are disproportionately exposed to harmful toxicants and are at an increased risk of developing an autoimmune disease. The aim of this study was to determine the association between POPs and TPOAbs in serum obtained from Native American women. This assessment was used to measure whether increased risk of autoimmune thyroid disease occurred as a result of exposure to POPs. Data were collected from 183 Akwesasne Mohawk women, 21-38 years of age, between 2009 and 2013. Multivariate analyses were conducted to determine the association between toxicant exposure and levels of TPOAbs. In multiple logistic regression analyses, exposure to PCB congener 33 was related to elevated risk of individuals possessing above normal levels of TPOAbs. Further, HCB was associated with more than 2-fold higher risk of possessing above normal levels of TPOAbs compared to women with normal levels of TPOAbs. -DDE was not associated with TPOAb levels within this study. Exposure to PCB congener 33 and HCB was correlated with above normal levels of TPOAbs, a marker of autoimmune thyroid disease. Additional investigations are needed to establish the causes and factors surrounding autoimmune thyroid disease which are multiple and complex.
持久性有机污染物 (POPs) 包括多氯联苯 (PCBs)、六氯苯 (HCB) 和滴滴涕 (-DDT)，据报道它们会影响免疫活性。作为内分泌干扰化学物质 (EDC)，这些污染物可能通过直接和间接影响甲状腺过氧化物酶抗体 (TPOAbs) 的水平来破坏正常的甲状腺功能，并作为自身免疫性甲状腺疾病发展的催化剂。美洲原住民社区不成比例地暴露于有害有毒物质中，患自身免疫性疾病的风险增加。本研究的目的是确定从美洲原住民妇女的血清中获得的 POPs 与 TPOAbs 之间的关联。这种评估用于测量由于暴露于 POPs 而导致自身免疫性甲状腺疾病的风险是否增加。该评估用于测量由于暴露于 POPs 而导致自身免疫性甲状腺疾病的风险是否增加。数据收集自 2009 年至 2013 年间年龄在 21-38 岁的 183 名阿克瓦萨斯内莫霍克族妇女。进行了多变量分析以确定有毒物质暴露与 TPOAbs 水平之间的关联。在多元逻辑回归分析中，暴露于 PCB 同系物 33 与个体具有高于正常 TPOAbs 水平的风险升高相关。此外，与 TPOAbs 水平正常的女性相比，HCB 与 TPOAbs 水平高于正常水平的风险增加了两倍以上。在本研究中，-DDE 与 TPOAb 水平无关。接触 PCB 同系物 33 和 HCB 与高于正常水平的 TPOAbs 相关，这是自身免疫性甲状腺疾病的标志物。需要进行进一步的调查，以确定自身免疫性甲状腺疾病的原因和周围因素，这些因素是多样且复杂的。
