遗传易感性、儿童期虐待与智商之间的关系：来自欧盟-基因互作研究多中心病例对照研究的结果。
The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case-control study.
机构信息
Department of Human Science, LUMSA University, Piazza delle Vaschette, 101, 00193, Rome, Italy.
Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, England.
出版信息
Soc Psychiatry Psychiatr Epidemiol. 2023 Oct;58(10):1573-1580. doi: 10.1007/s00127-023-02513-0. Epub 2023 Jun 19.
This study investigated if the association between childhood maltreatment and cognition among psychosis patients and community controls was partially accounted for by genetic liability for psychosis. Patients with first-episode psychosis (N = 755) and unaffected controls (N = 1219) from the EU-GEI study were assessed for childhood maltreatment, intelligence quotient (IQ), family history of psychosis (FH), and polygenic risk score for schizophrenia (SZ-PRS). Controlling for FH and SZ-PRS did not attenuate the association between childhood maltreatment and IQ in cases or controls. Findings suggest that these expressions of genetic liability cannot account for the lower levels of cognition found among adults maltreated in childhood.
这项研究调查了童年期虐待与精神病患者和社区对照人群认知之间的关联，是否部分可以由精神病的遗传易感性来解释。来自 EU-GEI 研究的首发精神病患者（N=755）和未受影响的对照者（N=1219）接受了童年期虐待、智商（IQ）、精神病家族史（FH）和精神分裂症多基因风险评分（SZ-PRS）的评估。控制 FH 和 SZ-PRS 并不能减轻病例或对照组中童年期虐待与 IQ 之间的关联。研究结果表明，这些遗传易感性的表现并不能解释在童年期受虐待的成年人认知水平较低的情况。
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