• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

遗传易感性、儿童期虐待与智商之间的关系：来自欧盟-基因互作研究多中心病例对照研究的结果。

The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case-control study.

机构信息

Department of Human Science, LUMSA University, Piazza delle Vaschette, 101, 00193, Rome, Italy.

Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, England.

出版信息

Soc Psychiatry Psychiatr Epidemiol. 2023 Oct;58(10):1573-1580. doi: 10.1007/s00127-023-02513-0. Epub 2023 Jun 19.

DOI:10.1007/s00127-023-02513-0
PMID:37335320
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10460355/
Abstract

This study investigated if the association between childhood maltreatment and cognition among psychosis patients and community controls was partially accounted for by genetic liability for psychosis. Patients with first-episode psychosis (N = 755) and unaffected controls (N = 1219) from the EU-GEI study were assessed for childhood maltreatment, intelligence quotient (IQ), family history of psychosis (FH), and polygenic risk score for schizophrenia (SZ-PRS). Controlling for FH and SZ-PRS did not attenuate the association between childhood maltreatment and IQ in cases or controls. Findings suggest that these expressions of genetic liability cannot account for the lower levels of cognition found among adults maltreated in childhood.

摘要

这项研究调查了童年期虐待与精神病患者和社区对照人群认知之间的关联，是否部分可以由精神病的遗传易感性来解释。来自 EU-GEI 研究的首发精神病患者（N=755）和未受影响的对照者（N=1219）接受了童年期虐待、智商（IQ）、精神病家族史（FH）和精神分裂症多基因风险评分（SZ-PRS）的评估。控制 FH 和 SZ-PRS 并不能减轻病例或对照组中童年期虐待与 IQ 之间的关联。研究结果表明，这些遗传易感性的表现并不能解释在童年期受虐待的成年人认知水平较低的情况。

相似文献

1
The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case-control study.遗传易感性、儿童期虐待与智商之间的关系：来自欧盟-基因互作研究多中心病例对照研究的结果。
Soc Psychiatry Psychiatr Epidemiol. 2023 Oct;58(10):1573-1580. doi: 10.1007/s00127-023-02513-0. Epub 2023 Jun 19.
2
Childhood Maltreatment, Educational Attainment, and IQ: Findings From a Multicentric Case-control Study of First-episode Psychosis (EU-GEI).儿童虐待、受教育程度和智商：首发精神病的多中心病例对照研究（EU-GEI）的结果。
Schizophr Bull. 2022 May 7;48(3):575-589. doi: 10.1093/schbul/sbac004.
3
Use of multiple polygenic risk scores for distinguishing schizophrenia-spectrum disorder and affective psychosis categories in a first-episode sample; the EU-GEI study.使用多个多基因风险评分区分首发样本中的精神分裂症谱系障碍和情感性精神病类别；EU-GEI 研究。
Psychol Med. 2023 Jun;53(8):3396-3405. doi: 10.1017/S0033291721005456. Epub 2022 Jan 25.
4
Synergistic effects of childhood adversity and polygenic risk in first-episode psychosis: the EU-GEI study.童年逆境与首发精神病多基因风险的协同作用：EU-GEI 研究。
Psychol Med. 2023 Apr;53(5):1970-1978. doi: 10.1017/S0033291721003664. Epub 2021 Sep 29.
5
Jumping to conclusions, general intelligence, and psychosis liability: findings from the multi-centre EU-GEI case-control study.草率下结论、一般智力与精神病倾向：来自多中心欧盟-基因-环境相互作用研究的结果。
Psychol Med. 2021 Mar;51(4):623-633. doi: 10.1017/S003329171900357X. Epub 2020 Apr 24.
6
The effect of polygenic risk score and childhood adversity on transdiagnostic symptom dimensions at first-episode psychosis: evidence for an affective pathway to psychosis.多基因风险评分和儿童逆境对首发精神病患者跨诊断症状维度的影响：精神病发生的情感途径的证据。
Transl Psychiatry. 2024 Oct 26;14(1):454. doi: 10.1038/s41398-024-03149-7.
7
The continuity of effect of schizophrenia polygenic risk score and patterns of cannabis use on transdiagnostic symptom dimensions at first-episode psychosis: findings from the EU-GEI study.精神分裂症多基因风险评分与大麻使用模式对首发精神病患者跨诊断症状维度的持续影响：EU-GEI 研究的结果。
Transl Psychiatry. 2021 Aug 10;11(1):423. doi: 10.1038/s41398-021-01526-0.
8
Interplay between Schizophrenia Polygenic Risk Score and Childhood Adversity in First-Presentation Psychotic Disorder: A Pilot Study.首发精神障碍中精神分裂症多基因风险评分与童年逆境之间的相互作用：一项初步研究。
PLoS One. 2016 Sep 20;11(9):e0163319. doi: 10.1371/journal.pone.0163319. eCollection 2016.
9
Facial Emotion Recognition in Psychosis and Associations With Polygenic Risk for Schizophrenia: Findings From the Multi-Center EU-GEI Case-Control Study.精神病患者的面部情绪识别与精神分裂症多基因风险的关联：来自多中心 EU-GEI 病例对照研究的结果。
Schizophr Bull. 2022 Sep 1;48(5):1104-1114. doi: 10.1093/schbul/sbac022.
10
First-Episode Psychosis Patients Who Deteriorated in the Premorbid Period Do Not Have Higher Polygenic Risk Scores Than Others: A Cluster Analysis of EU-GEI Data.首发精神病患者在病前阶段恶化者的多基因风险评分并不高于其他人：EU-GEI 数据的聚类分析。
Schizophr Bull. 2023 Jan 3;49(1):218-227. doi: 10.1093/schbul/sbac100.

引用本文的文献

1
The effect of polygenic risk score and childhood adversity on transdiagnostic symptom dimensions at first-episode psychosis: evidence for an affective pathway to psychosis.多基因风险评分和儿童逆境对首发精神病患者跨诊断症状维度的影响：精神病发生的情感途径的证据。
Transl Psychiatry. 2024 Oct 26;14(1):454. doi: 10.1038/s41398-024-03149-7.
2
Social exclusion as a major outcome domain of psychotic disorders: early predictors, and associations with non-recovery and clinical staging 21 years after a first episode of psychosis.社会排斥作为精神障碍的一个主要结局领域：早期预测因素，以及与首次精神病发作21年后未康复和临床分期的关联。
Soc Psychiatry Psychiatr Epidemiol. 2025 Feb;60(2):399-411. doi: 10.1007/s00127-024-02650-0. Epub 2024 May 21.

本文引用的文献

1
First-Episode Psychosis Patients Who Deteriorated in the Premorbid Period Do Not Have Higher Polygenic Risk Scores Than Others: A Cluster Analysis of EU-GEI Data.首发精神病患者在病前阶段恶化者的多基因风险评分并不高于其他人：EU-GEI 数据的聚类分析。
Schizophr Bull. 2023 Jan 3;49(1):218-227. doi: 10.1093/schbul/sbac100.
2
Schizophrenia Polygenic Risk and Experiences of Childhood Adversity: A Systematic Review and Meta-analysis.精神分裂症多基因风险与儿童期逆境经历：系统评价和荟萃分析。
Schizophr Bull. 2022 Sep 1;48(5):967-980. doi: 10.1093/schbul/sbac049.
3
Facial Emotion Recognition in Psychosis and Associations With Polygenic Risk for Schizophrenia: Findings From the Multi-Center EU-GEI Case-Control Study.精神病患者的面部情绪识别与精神分裂症多基因风险的关联：来自多中心 EU-GEI 病例对照研究的结果。
Schizophr Bull. 2022 Sep 1;48(5):1104-1114. doi: 10.1093/schbul/sbac022.
4
Family history of psychosis in youth at clinical high risk: A replication study.青年精神病临床高危家族史：一项复制研究。
Psychiatry Res. 2022 May;311:114480. doi: 10.1016/j.psychres.2022.114480. Epub 2022 Feb 24.
5
Childhood Maltreatment, Educational Attainment, and IQ: Findings From a Multicentric Case-control Study of First-episode Psychosis (EU-GEI).儿童虐待、受教育程度和智商：首发精神病的多中心病例对照研究（EU-GEI）的结果。
Schizophr Bull. 2022 May 7;48(3):575-589. doi: 10.1093/schbul/sbac004.
6
The continuity of effect of schizophrenia polygenic risk score and patterns of cannabis use on transdiagnostic symptom dimensions at first-episode psychosis: findings from the EU-GEI study.精神分裂症多基因风险评分与大麻使用模式对首发精神病患者跨诊断症状维度的持续影响：EU-GEI 研究的结果。
Transl Psychiatry. 2021 Aug 10;11(1):423. doi: 10.1038/s41398-021-01526-0.
7
Associations Between Schizophrenia Polygenic Liability, Symptom Dimensions, and Cognitive Ability in Schizophrenia.精神分裂症多基因风险、症状维度与精神分裂症认知能力的关联。
JAMA Psychiatry. 2021 Oct 1;78(10):1143-1151. doi: 10.1001/jamapsychiatry.2021.1961.
8
Cognitive functioning throughout adulthood and illness stages in individuals with psychotic disorders and their unaffected siblings.成年期和发病阶段个体的认知功能在精神病患者及其未受影响的兄弟姐妹中的表现。
Mol Psychiatry. 2021 Aug;26(8):4529-4543. doi: 10.1038/s41380-020-00969-z. Epub 2021 Jan 7.
9
Could Polygenic Risk Scores Be Useful in Psychiatry?: A Review.多基因风险评分在精神病学中的应用价值：综述。
JAMA Psychiatry. 2021 Feb 1;78(2):210-219. doi: 10.1001/jamapsychiatry.2020.3042.
10
From Basic Science to Clinical Application of Polygenic Risk Scores: A Primer.从多基因风险评分的基础科学到临床应用：入门指南。
JAMA Psychiatry. 2021 Jan 1;78(1):101-109. doi: 10.1001/jamapsychiatry.2020.3049.