Sun Guangshun, Wu Liangliang, Sun Guoqiang, Shi Xuesong, Cao Hongyong, Tang Weiwei
Department of General Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China.
Hepatobiliary/Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Living Donor Transplantation, Chinese Academy of Medical Sciences, Nanjing, Jiangsu, People's Republic of China.
Cancer Manag Res. 2021 Mar 16;13:2483-2498. doi: 10.2147/CMAR.S289819. eCollection 2021.
Despite the clinical development of new adjuvant and neoadjuvant chemotherapy drugs, colorectal cancer is still one of the leading causes of cancer-related death in human beings. WNT5a, an autocrine and paracrine β-catenin independent ligand, has been shown to induce tumor inhibition and carcinogenic signals, depending on the type of cancer. In patients with colorectal cancer, WNT5a triggers a variety of downstream signaling pathways, which mainly affect the migration and invasion of tumor cells. This article reviews the mechanism and therapeutic potential of WNT5a in colorectal cancer. In short, an in-depth understanding of the role of WNT5a in colorectal cancer is very helpful to better deal with this disease.
尽管新型辅助和新辅助化疗药物不断发展，但结直肠癌仍是人类癌症相关死亡的主要原因之一。WNT5a是一种自分泌和旁分泌的β-连环蛋白非依赖性配体，已被证明根据癌症类型可诱导肿瘤抑制和致癌信号。在结直肠癌患者中，WNT5a触发多种下游信号通路，主要影响肿瘤细胞的迁移和侵袭。本文综述了WNT5a在结直肠癌中的作用机制和治疗潜力。简而言之，深入了解WNT5a在结直肠癌中的作用对于更好地应对这种疾病非常有帮助。
