Donovan C M, Faulkner J A
J Appl Physiol (1985). 1986 Jul;61(1):288-92. doi: 10.1152/jappl.1986.61.1.288.
We hypothesized that the mass and maximum tetanic tension (Po) of nerve-intact grafts overloaded by ablation of synergistic muscles would be greater than that of standard nerve-intact grafts or of control soleus muscles. Soleus muscles were grafted orthotopically and bilaterally in 35 female rats. Control soleus muscles were obtained from 30 age-matched cohorts. Twenty-eight days following grafting, gastrocnemius muscles were ablated bilaterally in half of the animals. Comparisons were made between 28 and 112 days following grafting. By 112 days the wet mass of the overload nerve-intact grafts was 138% of the standard grafts and 152% of the control soleus muscles, whereas the Po was 161% and 107%, respectively. Specific tension stabilized at approximately 19 +/- 1 N/cm2 for both types of grafts, significantly lower than the value of 24 +/- 1 N/cm2 for control soleus muscles. Ablation of synergistic muscles resulted in a significant and sustained increase in mass and Po in regenerating skeletal muscle autografts. We conclude that provided the appropriate conditioning stimulus small grafts (100-200 mg) are capable of achieving the values for the mass and Po of control muscles.
我们推测，通过切除协同肌使神经完整的移植肌超载，其质量和最大强直张力（Po）将大于标准神经完整移植肌或对照比目鱼肌。在35只雌性大鼠中双侧原位移植比目鱼肌。从30只年龄匹配的大鼠获取对照比目鱼肌。移植后28天，对半数动物双侧切除腓肠肌。在移植后28天至112天之间进行比较。到112天时，超载神经完整移植肌的湿质量分别为标准移植肌的138%和对照比目鱼肌的152%，而Po分别为161%和107%。两种移植肌的比张力均稳定在约19±1N/cm2，显著低于对照比目鱼肌24±1N/cm2的值。切除协同肌导致再生骨骼肌自体移植肌的质量和Po显著且持续增加。我们得出结论，只要给予适当的调节刺激，小移植肌（100 - 200mg）能够达到对照肌的质量和Po值。
