Segal S S, White T P, Faulkner J A
Am J Physiol. 1986 Mar;250(3 Pt 1):C474-9. doi: 10.1152/ajpcell.1986.250.3.C474.
Skeletal muscle grafts have a deficit in tension development compared with control muscles, even after accounting for reduced mass and total muscle cross-sectional area. Our purpose was to determine relationships among the architecture, tissue composition, and contractile properties of rat soleus muscle grafts. Data were compared with control soleus muscles obtained from littermates. Female Wistar rats were anesthetized with pentobarbital sodium for grafting of soleus muscles with nerve implant and for dissection of muscles 56 days after grafting. Compared with control values, the maximum specific tension (N/cm2) of grafts was 76%, the interstitial (inulin) space was 135%, and the connective tissue protein concentration was 177%. For grafts, total muscle length and fiber length were 91 and 123% of control values, respectively. The extrapolated shortening velocity at zero load (fiber lengths/s) for grafts was not different from the control value. The deficit in specific tension of grafts is explained by a greater concentration of noncontractile tissue components. Changes in muscle architecture and composition following grafting had little affect on contraction dynamics.
与对照肌肉相比，即使在考虑了质量减轻和总肌肉横截面积之后，骨骼肌移植物在张力发展方面仍存在不足。我们的目的是确定大鼠比目鱼肌移植物的结构、组织组成和收缩特性之间的关系。将数据与从同窝出生的大鼠获取的对照比目鱼肌进行比较。雌性Wistar大鼠用戊巴比妥钠麻醉，用于比目鱼肌移植及神经植入，并在移植后56天进行肌肉解剖。与对照值相比，移植物的最大比张力（N/cm²）为76%，间质（菊粉）间隙为135%，结缔组织蛋白浓度为177%。对于移植物，总肌肉长度和纤维长度分别为对照值的91%和123%。移植物在零负荷下的外推缩短速度（纤维长度/秒）与对照值无差异。移植物比张力的不足是由非收缩性组织成分的浓度较高所致。移植后肌肉结构和组成的变化对收缩动力学影响很小。
