Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization, Sichuan Province and Ministry of Education, Southwest Minzu University, Chengdu, Sichuan 610041, People's Republic of China.
Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization, Sichuan Province and Ministry of Education, Southwest Minzu University, Chengdu, Sichuan 610041, People's Republic of China.
Gene. 2023 Aug 20;878:147574. doi: 10.1016/j.gene.2023.147574. Epub 2023 Jun 17.
Ubiquitination is a widespread post-transcriptional modification (PTM) that occurs during protein degradation in eukaryotes and participates in almost all physiological and pathological processes, including animal adipogenesis. Ubiquitination is a cascade reaction regulated by the activating enzyme E1, conjugating enzyme E2, and ligase E3. Several recent studies have reported that E3 ligases play important regulatory roles in adipogenesis. However, as a key influencing factor for the recognition and connection between the substrate and ubiquitin during ubiquitination, its regulatory role in adipogenesis has not received adequate attention. In this review, we summarize the E3s' regulation and modification targets in animal adipogenesis, explain the regulatory mechanisms in lipogenic-related pathways, and further analyze the existing positive results to provide research directions of guiding significance for further studies on the regulatory mechanisms of E3s in animal adipogenesis.
泛素化是一种广泛存在的转录后修饰（PTM），发生在真核生物的蛋白质降解过程中，参与几乎所有的生理和病理过程，包括动物脂肪生成。泛素化是由激活酶 E1、连接酶 E2 和连接酶 E3 调节的级联反应。最近的几项研究表明，E3 连接酶在脂肪生成中发挥着重要的调节作用。然而，作为泛素化过程中底物和泛素之间识别和连接的关键影响因素，其在脂肪生成中的调节作用尚未得到足够的重视。在这篇综述中，我们总结了 E3 在动物脂肪生成中的调节和修饰靶标，解释了在脂肪生成相关途径中的调节机制，并进一步分析了现有的积极结果，为进一步研究 E3 在动物脂肪生成中的调节机制提供了具有指导意义的研究方向。
