Hansz J, Prazmowska-Owczarek B, Nowicka G
Acta Haematol Pol. 1979 Jan-Mar;10(1):7-12.
In 36 patients with stage III and IV of Hodgkin's disease granulocyte adherence was investigated. The determinations were carried out in minicolumns filled with nylon fibres. In 13 patients the determinations were repeated 2, 4, 6, 12 and 24 hours after administration of vinblastine and cyclophosphamide. In all patients granulocyte adherence was reduced, by 54.1 +/- 3.5% on the average. The values of adherence in the control group were of the order of 83.7 +/- +/- 4.7%. Administration of antiproliferative drugs reduced further the adherence. The lowest value of it was observed 6 hours after vinblastine and cyclophosphamide administration. After that time the adherence increased gradually reaching the initial level 24 hours after administration of antiproliferative agents. These results suggest that reduced adherence of granulocytes may be an additional cause, besides abnormal immunological reactions, of the impairment of the resistance mechanisms of the organism in advanced stages of Hodgkin's disease.
对36例Ⅲ期和Ⅳ期霍奇金病患者的粒细胞黏附情况进行了研究。测定在填充尼龙纤维的微型柱中进行。13例患者在给予长春碱和环磷酰胺后2、4、6、12和24小时重复进行测定。所有患者的粒细胞黏附均降低，平均降低54.1±3.5%。对照组的黏附值约为83.7±4.7%。给予抗增殖药物后进一步降低了黏附。在给予长春碱和环磷酰胺后6小时观察到最低值。此后，黏附逐渐增加，在给予抗增殖药物24小时后达到初始水平。这些结果表明，粒细胞黏附降低可能是除异常免疫反应外，霍奇金病晚期机体抵抗机制受损的另一个原因。
