Prazmowska-Owczarek B, Hansz J
Z Gesamte Inn Med. 1981 Sep 15;36(18):678-80.
In 30 adult patients with III and IV Hodgkin's disease the studies of granulocytic turnover were performed. Bone marrow storage pool was measured by hydrocortisone test. Total blood granulocyte pool was judged by the estimation of muramidase activity and serum unsaturated vitamin B12 binding capacity. The epinephrine test was used for the marginated granulocyte pool determination. The circulating granulocyte pool was calculated from the count of granulocytes in the samples of venous blood. The tissue mobilization of granulocytes was measured by Senn's et al. method. After hydrocortisone application the releasing of the mature granulocytes from the bone-marrow was significantly lower in patients with Hodgkin's disease than in controls. The circulating and marginated pools of granulocytes in Hodgkin's disease did not differ from the normal persons. The tissue migration of granulocytes was decreased in patients with Hodgkin's disease. It is concluded that these abnormalities of granulocytic turnover in advanced Hodgkin's disease may be considered to be an additional cause of the defence mechanism in this disease.
对30例Ⅲ期和Ⅳ期霍奇金病成年患者进行了粒细胞周转率研究。通过氢化可的松试验测量骨髓储存池。通过测定溶菌酶活性和血清不饱和维生素B12结合能力来判断全血粒细胞池。肾上腺素试验用于确定边缘粒细胞池。循环粒细胞池由静脉血样本中的粒细胞计数计算得出。采用森氏等人的方法测量粒细胞的组织动员。应用氢化可的松后，霍奇金病患者骨髓中成熟粒细胞的释放明显低于对照组。霍奇金病患者粒细胞的循环池和边缘池与正常人无差异。霍奇金病患者粒细胞的组织迁移减少。结论是，晚期霍奇金病粒细胞周转率的这些异常可能被认为是该疾病防御机制的另一个原因。
